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Tumor inhibiting properties of stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes. Part I. Synthesis

Jennerwein, Margaretha and Gust, Ronald and Müller, Richard and Schönenberger, Helmut and Engel, Juergen and Berger, Martin R. and Schmaehl, Dietrich and Seeber, Siegfried and Osieka, Reinhardt (1989) Tumor inhibiting properties of stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes. Part I. Synthesis. Archiv der Pharmazie 322 (1), pp. 25-29.

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Abstract

The prepn. of stereoisomeric 1,2-bis(3-hydroxyphenyl)ethylenediamines (L) from meso-1,2-bis(2-hydroxyphenyl)ethylenediamine and 3-methoxybenzaldehyde by a diaza-Cope-rearrangement and subsequent ether cleavage with BBr3 and their conversion to PtLCl2 with K2PtCl4 are described. PtLCl2 were characterized by CD, IR and NMR ...

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Item Type:Article
Date:1989
Additional information (public):CAN 110:224375 78-7 Inorganic Chemicals and Reactions 591-31-1 (3-Methoxybenzaldehyde) Role: RCT (Reactant), RACT (Reactant or reagent) (condensation reaction of, with diphenylethylenediamines followed by diaza-Cope rearrangement and ether cleavage by boron tribromide); 58519-80-5 (meso-1,2-Bis(2-hydroxyphenyl)ethylenediamine) Role: RCT (Reactant), RACT (Reactant or reagent) (condensation reaction of, with methoxybenzaldehyde followed by diaza Cope rearrangement and ether cleavage); 119386-71-9P Role: RCT (Reactant), PREP (Preparation), RACT (Reactant or reagent) (formation and reaction of, with methoxybenzaldehyde followed by diaza-Cope rearrangement and ether cleavage by boron tribromide); 119386-70-8P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and ether cleavage by boron tribromide and resoln. of, by tartaric acid); 93913-16-7P; 119435-17-5P; 120665-17-0P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and ether cleavage of, by boron tribromide); 119386-69-5P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and hydrolysis of, followed by cleavage reaction with boron tribromide); 93856-31-6P; 93913-25-8P; 93983-45-0P; 119386-68-4P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and proton NMR of); 119435-15-3P; 119435-16-4P; 119479-53-7P; 119479-54-8P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 10025-99-7 (Dipotassium tetrachloroplatinate(2-) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with bis(hydroxyphenyl)ethylenediamine stereoisomers)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1989:224375Other
Keywords:Isomerism and Isomers (stereo-, of bis(3-hydroxyphenyl)ethylenediamine and their platinum complexes) hydroxyphenylethylenediamine stereoisomer platinum hydroxyphenylethylenediamine stereoisomer amine hydroxyphenylethylenedi platinum stereoisomer
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 08:07
Last Modified:12 Nov 2010 08:07
Item ID:17673
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