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Tumor inhibiting properties of stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II)-complexes. Part II. Biological properties

Jennerwein, Margaretha and Gust, Ronald and Müller, Richard and Schönenberger, Helmut and Engel, Juergen and Berger, Martin R. and Schmaehl, Dietrich and Seeber, Siegfried and Osieka, Reinhardt (1989) Tumor inhibiting properties of stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II)-complexes. Part II. Biological properties. Archiv der Pharmazie 322 (2), pp. 67-73.

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Abstract

The antitumor activity of stereoisomers of the title complex (I) in several tumor models (MDA-MB 231 breast cancer cell line; mouse P 388 leukemia, mouse L 1210 leukemia, rat L 5222 leukemia, and mouse wild-type Ehrlich ascites tumor resistant to cisplatin, etoposide, cyclophosphamide, and daunomycin, resp.) is described. For comparison, the analogous ...

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Item Type:Article
Date:1989
Additional information (public):CAN 110:147201 1-3 Pharmacology 15663-27-1 (Cisplatin) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (antitumor activity of platinum complex stereoisomers in combination with); 7440-06-4D (Platinum); 91265-66-6; 91326-61-3; 91326-62-4; 91326-63-5; 93856-31-6; 93983-45-0; 119479-53-7; 119479-54-8 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (antitumor activity of, stereoselectivity of)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1989:147201Other
Keywords:Neoplasm inhibitors ([(hydroxyphenyl)ethylenediamine]dichloroplatinum(II) stereoisomer complexes) Molecular structure-biological activity relationship (neoplasm-inhibiting, of [(hydroxyphenyl)ethylenediamine]dichloroplatinum(II) stereoisomer complexes) platinum complex stereoisomer antitumor structure
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 07:33
Last Modified:12 Nov 2010 07:33
Item ID:17674
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