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Investigations on the antiproliferative effects of amino acid antagonists targeting for aminoacyl-tRNA synthetases. Part II. The antileukemic effect

Laske, Reiner and Schönenberger, Helmut and Holler, Eggehard (1989) Investigations on the antiproliferative effects of amino acid antagonists targeting for aminoacyl-tRNA synthetases. Part II. The antileukemic effect. Archiv der Pharmazie 322 (12), pp. 857-862.

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Abstract

Amino acid antagonists with proven or potential inhibitory activities on aminoacyl-tRNA synthetases were tested for their antiproliferative effect against the murine leukemic cell line P338D1. Micromolar concns. of the compds. S-tritylcysteine, fenitropan, and beta -chloroalanine were markedly inhibitory. In the mouse only S-tritylcysteine was effective against leukemia P388 (T/C = 211%). The ...

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Item Type:Article
Date:1989
Additional information (public):CAN 112:111625 1-6 Pharmacology 50-67-9 (5-Hydroxytryptamine); 51-61-6 (Dopamine); 51-65-0 (DL-4-Fluorophenylalanine); 51-67-2 (Tyramine); 56-12-2; 60-23-1 (Cysteamine); 61-54-1 (Tryptamine); 62-57-7 (2-Aminoisobutyric acid); 63-84-3 (DL-3,4-Dihydroxyphenylalanine); 64-12-0 (DL-p-Chloroamphetamine); 67-21-0 (DL-Ethionine); 70-78-0 (3-Iodo-L-tyrosine); 103-01-5 (N-Phenylglycine); 104-63-2 (N-Benzylethanolamine); 153-44-6 (beta -Methyl-DL-tryptophan); 153-91-3 (alpha -Methyl-DL-tryptophan); 299-26-3; 403-90-7 (DL-3-Fluorotyrosine); 405-39-0; 443-80-1; 456-88-2 (DL-3-Fluorophenylalanine); 500-44-7; 526-31-8; 536-33-4 (Ethionamide); 541-48-0 (DL-3-Aminobutyric acid); 543-38-4; 552-85-2; 587-20-2 (alpha -Methylhistidine); 621-44-3 (3-Nitro-L-tyrosine); 671-42-1 (DL-alpha -Amino-e-caprolactam); 687-51-4 (L-Leucinamide); 760-78-1 (DL-Norvaline); 951-55-3 (5-Methyl-DL-tryptophan); 979-92-0 (S-Adenosyl-L-homocysteine); 1113-41-3 (L-Penicillamine); 1132-26-9 (alpha -Methyl-DL-phenylalanine); 1138-80-3; 1149-26-4; 1464-42-2 (Seleno-DL-methionine); 1483-07-4 (Albizziin); 1955-68-6; 2021-58-1 (beta -2-Thienyl-DL-alanine); 2133-34-8 (L-Azetidine-2-carboxylic acid); 2260-12-0 (beta -Methyl-DL-phenylalanine); 2280-42-4 (DL-beta -Hydroxynorvaline); 2629-55-2 (DL-2-Fluorophenylalanine); 2697-61-2 (Selenocystamine); 2731-73-9 (L-beta -Chloroalanine); 2749-07-7 (alpha -Methyl-DL-methionine); 2792-72-5; 2799-07-7 (S-Trityl-L-cysteine); 2897-21-4 (DL-Selenocystine); 2899-37-8 (L-Methioninol); 2935-35-5 (L-alpha -Phenylglycine); 2936-69-8 (L-4-Thialysine); 3182-95-4 (L-Phenylalaninol); 3251-08-9; 3395-35-5 (DL-3,4-Dehydroproline); 3647-71-0 (N-Benzyl-2-phenylethylamine); 4144-02-9; 4350-09-8 (L-5-Hydroxytryptophan); 4746-36-5 (DL-4-Azaleucine); 4836-52-6 (L-Histidinol); 5034-68-4 (L-Tyrosinol); 6232-19-5 (beta -Cyano-L-alanine); 6645-45-0; 6829-40-9 (Aminomalonic acid diethyl ester); 7303-50-6 (DL-7-Azatryptophan); 7533-40-6 (L-Leucinol); 7695-56-9 (DL-threo-beta -Phenylserine); 7730-20-3 (DL-6-Fluorotryptophan); 10065-72-2 (L-Alanine methyl ester); 13004-62-1 (trans-2,6-Diaminohex-4-enoic acid); 14954-40-6; 16063-80-2; 16120-92-6; 16748-73-5 (L-Aspartic acid diamide); 17332-70-6 (7-Methyl-DL-tryptophan); 17463-43-3 (3,3,3-Trifluoro-DL-alanine); 17480-69-2 (N-Benzyl-D-amphetamine); 17781-05-4; 18625-03-1; 18865-31-1; 19461-04-2 (N-Benzyl-L-phenylalanine); 23220-52-2 (meso-2,3-Diaminosuccinic acid); 24629-25-2; 25125-92-2; 25631-05-4 (DL-4-Fluorotryptophan); 26340-83-0; 26988-72-7 (1-Methyl-DL-tryptophan); 28057-52-5 (L-Isoasparagine); 28143-91-1; 34592-47-7; 40172-05-2; 52153-41-0; 54542-13-1; 55779-32-3; 57601-68-0; 57734-57-3 (2-Aminomethylpyrrolidine); 60046-47-1; 65934-95-4 (Fenitropan); 75543-73-6; 80300-21-6; 80300-23-8; 91531-30-5 (Antineoplaston A10); 108321-88-6; 124081-74-9; 125293-76-7; 125293-77-8; 125293-79-0 (DL-2,6-Diphthalimidocaproic acid methyl ester); 125293-80-3; 125293-81-4; 125293-82-5; 125293-83-6; 125293-85-8; 125293-86-9; 125356-75-4; 125729-28-4 Role: BIOL (Biological study) (amino acid antagonist, aminoacyl tRNA synthetase inhibitory and antileukemic activities of); 52-90-4 (Cysteine); 56-40-6 (Glycine); 56-41-7 (L-Alanine); 56-84-8 (Aspartic acid); 56-85-9 (Glutamine); 56-86-0 (Glutamic acid); 70-47-3 (Asparagine); 71-00-1 (Histidine); 73-32-5 (Isoleucine); 74-79-3 (L-Arginine) Role: BIOL (Biological study) (antagonists, aminoacyl tRNA synthetase inhibitory and antileukemic activities of); 56-45-1 (L-Serine); 56-87-1 (L-Lysine); 60-18-4 (L-Tyrosine); 61-90-5 (L-Leucine); 63-68-3 (L-Methionine); 63-91-2 (L-Phenylalanine); 72-18-4 (L-Valine); 72-19-5 (L-Threonine); 147-85-3 (L-Proline) Role: BIOL (Biological study) (antagonists, aminoacyl-tRNA synthetase and antileukemia activities of); 9028-02-8 (Aminoacyl tRNA synthetase) Role: PROC (Process) (inhibition of, by amino acid antagonist, antileukemia activities of)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1990:111625Other
Keywords:Amino acids Role: BIOL (Biological study) (antagonists, aminoacyl tRNA synthetase inhibitory and antileukemic activities of) Neoplasm inhibitors (leukemia, amino acid antagonists as, aminoacyl tRNA synthetase inhibition in relation to) amino acid antagonist antiproliferation tRNA synthetase
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 07:31
Last Modified:12 Nov 2010 07:31
Item ID:17675
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