Startseite UR

Investigations on the antiproliferative effects of amino acid antagonists targeting for aminoacyl-tRNA synthetases. Part II. The antileukemic effect

Laske, Reiner und Schönenberger, Helmut und Holler, Eggehard (1989) Investigations on the antiproliferative effects of amino acid antagonists targeting for aminoacyl-tRNA synthetases. Part II. The antileukemic effect. Archiv der Pharmazie 322 (12), S. 857-862.

Im Publikationsserver gibt es leider keinen Volltext zu diesem Eintrag.


Zusammenfassung

Amino acid antagonists with proven or potential inhibitory activities on aminoacyl-tRNA synthetases were tested for their antiproliferative effect against the murine leukemic cell line P338D1. Micromolar concns. of the compds. S-tritylcysteine, fenitropan, and beta -chloroalanine were markedly inhibitory. In the mouse only S-tritylcysteine was effective against leukemia P388 (T/C = 211%). The ...

plus


Bibliographische Daten exportieren



Dokumentenart:Artikel
Datum:1989
Zusätzliche Informationen (Öffentlich):CAN 112:111625 1-6 Pharmacology 50-67-9 (5-Hydroxytryptamine); 51-61-6 (Dopamine); 51-65-0 (DL-4-Fluorophenylalanine); 51-67-2 (Tyramine); 56-12-2; 60-23-1 (Cysteamine); 61-54-1 (Tryptamine); 62-57-7 (2-Aminoisobutyric acid); 63-84-3 (DL-3,4-Dihydroxyphenylalanine); 64-12-0 (DL-p-Chloroamphetamine); 67-21-0 (DL-Ethionine); 70-78-0 (3-Iodo-L-tyrosine); 103-01-5 (N-Phenylglycine); 104-63-2 (N-Benzylethanolamine); 153-44-6 (beta -Methyl-DL-tryptophan); 153-91-3 (alpha -Methyl-DL-tryptophan); 299-26-3; 403-90-7 (DL-3-Fluorotyrosine); 405-39-0; 443-80-1; 456-88-2 (DL-3-Fluorophenylalanine); 500-44-7; 526-31-8; 536-33-4 (Ethionamide); 541-48-0 (DL-3-Aminobutyric acid); 543-38-4; 552-85-2; 587-20-2 (alpha -Methylhistidine); 621-44-3 (3-Nitro-L-tyrosine); 671-42-1 (DL-alpha -Amino-e-caprolactam); 687-51-4 (L-Leucinamide); 760-78-1 (DL-Norvaline); 951-55-3 (5-Methyl-DL-tryptophan); 979-92-0 (S-Adenosyl-L-homocysteine); 1113-41-3 (L-Penicillamine); 1132-26-9 (alpha -Methyl-DL-phenylalanine); 1138-80-3; 1149-26-4; 1464-42-2 (Seleno-DL-methionine); 1483-07-4 (Albizziin); 1955-68-6; 2021-58-1 (beta -2-Thienyl-DL-alanine); 2133-34-8 (L-Azetidine-2-carboxylic acid); 2260-12-0 (beta -Methyl-DL-phenylalanine); 2280-42-4 (DL-beta -Hydroxynorvaline); 2629-55-2 (DL-2-Fluorophenylalanine); 2697-61-2 (Selenocystamine); 2731-73-9 (L-beta -Chloroalanine); 2749-07-7 (alpha -Methyl-DL-methionine); 2792-72-5; 2799-07-7 (S-Trityl-L-cysteine); 2897-21-4 (DL-Selenocystine); 2899-37-8 (L-Methioninol); 2935-35-5 (L-alpha -Phenylglycine); 2936-69-8 (L-4-Thialysine); 3182-95-4 (L-Phenylalaninol); 3251-08-9; 3395-35-5 (DL-3,4-Dehydroproline); 3647-71-0 (N-Benzyl-2-phenylethylamine); 4144-02-9; 4350-09-8 (L-5-Hydroxytryptophan); 4746-36-5 (DL-4-Azaleucine); 4836-52-6 (L-Histidinol); 5034-68-4 (L-Tyrosinol); 6232-19-5 (beta -Cyano-L-alanine); 6645-45-0; 6829-40-9 (Aminomalonic acid diethyl ester); 7303-50-6 (DL-7-Azatryptophan); 7533-40-6 (L-Leucinol); 7695-56-9 (DL-threo-beta -Phenylserine); 7730-20-3 (DL-6-Fluorotryptophan); 10065-72-2 (L-Alanine methyl ester); 13004-62-1 (trans-2,6-Diaminohex-4-enoic acid); 14954-40-6; 16063-80-2; 16120-92-6; 16748-73-5 (L-Aspartic acid diamide); 17332-70-6 (7-Methyl-DL-tryptophan); 17463-43-3 (3,3,3-Trifluoro-DL-alanine); 17480-69-2 (N-Benzyl-D-amphetamine); 17781-05-4; 18625-03-1; 18865-31-1; 19461-04-2 (N-Benzyl-L-phenylalanine); 23220-52-2 (meso-2,3-Diaminosuccinic acid); 24629-25-2; 25125-92-2; 25631-05-4 (DL-4-Fluorotryptophan); 26340-83-0; 26988-72-7 (1-Methyl-DL-tryptophan); 28057-52-5 (L-Isoasparagine); 28143-91-1; 34592-47-7; 40172-05-2; 52153-41-0; 54542-13-1; 55779-32-3; 57601-68-0; 57734-57-3 (2-Aminomethylpyrrolidine); 60046-47-1; 65934-95-4 (Fenitropan); 75543-73-6; 80300-21-6; 80300-23-8; 91531-30-5 (Antineoplaston A10); 108321-88-6; 124081-74-9; 125293-76-7; 125293-77-8; 125293-79-0 (DL-2,6-Diphthalimidocaproic acid methyl ester); 125293-80-3; 125293-81-4; 125293-82-5; 125293-83-6; 125293-85-8; 125293-86-9; 125356-75-4; 125729-28-4 Role: BIOL (Biological study) (amino acid antagonist, aminoacyl tRNA synthetase inhibitory and antileukemic activities of); 52-90-4 (Cysteine); 56-40-6 (Glycine); 56-41-7 (L-Alanine); 56-84-8 (Aspartic acid); 56-85-9 (Glutamine); 56-86-0 (Glutamic acid); 70-47-3 (Asparagine); 71-00-1 (Histidine); 73-32-5 (Isoleucine); 74-79-3 (L-Arginine) Role: BIOL (Biological study) (antagonists, aminoacyl tRNA synthetase inhibitory and antileukemic activities of); 56-45-1 (L-Serine); 56-87-1 (L-Lysine); 60-18-4 (L-Tyrosine); 61-90-5 (L-Leucine); 63-68-3 (L-Methionine); 63-91-2 (L-Phenylalanine); 72-18-4 (L-Valine); 72-19-5 (L-Threonine); 147-85-3 (L-Proline) Role: BIOL (Biological study) (antagonists, aminoacyl-tRNA synthetase and antileukemia activities of); 9028-02-8 (Aminoacyl tRNA synthetase) Role: PROC (Process) (inhibition of, by amino acid antagonist, antileukemia activities of)
Institutionen:Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Schönenberger
Projekte:SFB 234
Identifikationsnummer:
WertTyp
1990:111625Andere
Stichwörter / Keywords:Amino acids Role: BIOL (Biological study) (antagonists, aminoacyl tRNA synthetase inhibitory and antileukemic activities of) Neoplasm inhibitors (leukemia, amino acid antagonists as, aminoacyl tRNA synthetase inhibition in relation to) amino acid antagonist antiproliferation tRNA synthetase
Dewey-Dezimal-Klassifikation:500 Naturwissenschaften und Mathematik > 540 Chemie
Status:Veröffentlicht
Begutachtet:Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:Ja
Eingebracht am:12 Nov 2010 07:31
Zuletzt geändert:12 Nov 2010 07:31
Dokumenten-ID:17675
Nur für Besitzer und Autoren: Kontrollseite des Eintrags
  1. Universität

Universitätsbibliothek

Publikationsserver

Kontakt:

Publizieren: oa@ur.de

Dissertationen: dissertationen@ur.de

Forschungsdaten: daten@ur.de

Ansprechpartner