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Rationale for combining tamoxifen and interferon in the treatment of advanced breast cancer

Porzsolt, F. and Otto, A. M. and Trauschel, B. and Buck, C. and Wawer, A. W. and Schönenberger, Helmut (1989) Rationale for combining tamoxifen and interferon in the treatment of advanced breast cancer. Journal of cancer research and clinical oncology 115 (5), pp. 465-469.

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Abstract

Several investigators have discussed the possible combination of tamoxifen and interferon (IFN) in the treatment of breast cancer patients. The rationale in combining these drugs is that IFN induces the expression of estrogen receptors and therefore increases the sensitivity of breast cancer cells toward the growth-inhibitory activity of tamoxifen. In this paper we review the literature on the ...

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Item Type:Article
Date:1989
Additional information (public):GERMANY, WEST: Germany, Federal Republic of 10540-29-1 (Tamoxifen); 9008-11-1 (Interferons)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1990037149Other
Keywords:Antineoplastic Combined Chemotherapy Protocols: PD, pharmacology *Antineoplastic Combined Chemotherapy Protocols: TU, therapeutic use Breast Neoplasms: AN, analysis *Breast Neoplasms: DT, drug therapy Breast Neoplasms: PA, pathology Humans *Interferons: AD, administration & dosage Receptors, Estrogen: AN, analysis *Tamoxifen: AD, administration & dosage Tumor Cells, Cultured: DE, drug effects 0 (Receptors, Estrogen)
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 07:30
Last Modified:12 Nov 2010 07:30
Item ID:17676
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