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Ester derivatives of the mammary-tumor-inhibiting antiestrogen 2,3-bis(2-fluoro-4-hydroxyphenyl)-2,3-dimethylbutane

Schwarz, W. and Hartmann, R. W. and Engel, J. and Schneider, M. R. and Schönenberger, Helmut (1989) Ester derivatives of the mammary-tumor-inhibiting antiestrogen 2,3-bis(2-fluoro-4-hydroxyphenyl)-2,3-dimethylbutane. Journal of cancer research and clinical oncology 115 (2), pp. 161-165.

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Abstract

The synthesis of the bisacetate (8), the bisdichloroacetate (9), the biscarbamate (10) and the bisphosphate (11) of the "partial" antiestrogen 2,3-bis(2-fluoro-4-hydroxyphenyl)-2,3-dimethylbutane (7) is described. In the case of 8-10 the introduction of ester functions slightly reduces the estrogen receptor affinity of 7. However, it was strongly diminished in 11. Compared with 7 the estrogenic ...

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Item Type:Article
Date:1989
Additional information (public):GERMANY, WEST: Germany, Federal Republic of
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1989234138Other
Keywords:Animals *Antineoplastic Agents Binding, Competitive Estrogen Antagonists: CS, chemical synthesis *Estrogen Antagonists: PD, pharmacology Mammary Neoplasms, Experimental: ME, metabolism Mammary Neoplasms, Experimental: PA, pathology *Mammary Neoplasms, Experimental: PC, prevention & control Mice Receptors, Estradiol: DE, drug effects 0 (Antineoplastic Agents) 0 (Estrogen Antagonists) 0 (Receptors, Estradiol)
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 07:26
Last Modified:12 Nov 2010 07:26
Item ID:17678
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