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Synthesis and antitumor activity of platinum(II) complexes containing substituted ethylenediamine ligands

Brunner, Henri and Hankofer, Peter and Holzinger, Ulrich and Treittinger, Barbara and Schönenberger, Helmut (1990) Synthesis and antitumor activity of platinum(II) complexes containing substituted ethylenediamine ligands. European journal of medicinal chemistry. 25 (1), pp. 35-44.

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Abstract

The prepn. of substituted ethylenediamines, their reactions with K2PtCl4 to give the dichloroplatinum(II) complexes, and the exchange of the chloro ligands for other leaving groups are described. The new compds. were tested as antitumor agents both in vitro using the hormone independent human mammary carcinoma cell line MDA-MB 231 as well as in vivo using the lymphocytic P388 leukemia of the ...

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Item Type:Article
Date:1990
Additional information (public):CAN 113:107966 78-7 Inorganic Chemicals and Reactions 51-31-0; 2627-86-3 Role: RCT (Reactant), RACT (Reactant or reagent) (amidation by, of benzyloxycarbonylphenylalanine); 3588-57-6 Role: RCT (Reactant), RACT (Reactant or reagent) (amidation of, with isopropylamine); 29622-19-3P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and amidation of, followed by redn.); 105368-95-4P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and anionic exchange and antitumor activity of racemic); 72426-83-6P; 102050-52-2P; 105237-00-1P; 105308-31-4P; 105856-64-2P; 105856-65-3P; 105870-24-4P; 128610-09-3P; 128610-10-6P; 128610-12-8P; 128610-14-0P; 128610-15-1P; 128610-16-2P; 128636-07-7P; 128636-08-8P; 128636-09-9P; 128636-10-2P; 128636-11-3P; 128636-13-5P; 128636-14-6P; 128658-76-4P; 128658-77-5P; 128705-27-1P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. and antitumor activity of); 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Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1990:507966Other
Keywords:Neoplasm inhibitors (platinate chloro substituted-ethylendiamine complexes) Amino acids Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and esterification of, followed by amidation and redn.) platinate chloro substituted ethylenediamine antitumor activity platinate chloro substituted ethylenediamine amino acid esterification amination amino acid ester amide prepn redn
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 07:24
Last Modified:12 Nov 2010 07:24
Item ID:17679
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