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Synthesis and antitumor activity of platinum(II) complexes containing substituted ethylenediamine ligands

Brunner, Henri und Hankofer, Peter und Holzinger, Ulrich und Treittinger, Barbara und Schönenberger, Helmut (1990) Synthesis and antitumor activity of platinum(II) complexes containing substituted ethylenediamine ligands. European journal of medicinal chemistry. 25 (1), S. 35-44.

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Zusammenfassung

The prepn. of substituted ethylenediamines, their reactions with K2PtCl4 to give the dichloroplatinum(II) complexes, and the exchange of the chloro ligands for other leaving groups are described. The new compds. were tested as antitumor agents both in vitro using the hormone independent human mammary carcinoma cell line MDA-MB 231 as well as in vivo using the lymphocytic P388 leukemia of the ...

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Dokumentenart:Artikel
Datum:1990
Zusätzliche Informationen (Öffentlich):CAN 113:107966 78-7 Inorganic Chemicals and Reactions 51-31-0; 2627-86-3 Role: RCT (Reactant), RACT (Reactant or reagent) (amidation by, of benzyloxycarbonylphenylalanine); 3588-57-6 Role: RCT (Reactant), RACT (Reactant or reagent) (amidation of, with isopropylamine); 29622-19-3P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and amidation of, followed by redn.); 105368-95-4P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and anionic exchange and antitumor activity of racemic); 72426-83-6P; 102050-52-2P; 105237-00-1P; 105308-31-4P; 105856-64-2P; 105856-65-3P; 105870-24-4P; 128610-09-3P; 128610-10-6P; 128610-12-8P; 128610-14-0P; 128610-15-1P; 128610-16-2P; 128636-07-7P; 128636-08-8P; 128636-09-9P; 128636-10-2P; 128636-11-3P; 128636-13-5P; 128636-14-6P; 128658-76-4P; 128658-77-5P; 128705-27-1P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. and antitumor activity of); 105237-01-2P; 105237-02-3P; 105237-03-4P; 105237-04-5P; 105237-05-6P; 105856-39-1P; 105856-40-4P; 105856-49-3P; 105856-52-8P; 105856-54-0P; 105856-55-1P; 105856-56-2P; 105856-57-3P; 105856-58-4P; 105856-59-5P; 105856-61-9P; 105870-25-5P; 128594-51-4P; 128594-52-5P; 128594-53-6P; 128594-54-7P; 128594-55-8P; 128594-56-9P; 128594-57-0P; 128594-58-1P; 128594-59-2P; 128594-60-5P; 128594-61-6P; 128594-62-7P; 128594-63-8P; 128594-69-4P; 128610-20-8P; 128610-21-9P; 128610-23-1P; 128610-24-2P; 128610-25-3P; 128636-06-6P; 128705-23-7P; 128705-24-8P; 128705-25-9P; 128705-26-0P; 128705-28-2P; 128705-29-3P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and antitumor activity of racemic); 104907-23-5P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and cleavage of); 3321-96-8P; 4441-50-3P; 14108-60-2P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and esterification of, followed by amidation and redn.); 51-65-0P; 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68319-33-5P; 81375-37-3P; 108945-12-6P; 128834-04-8P; 128834-05-9P; 128834-06-0P; 128834-08-2P; 128834-09-3P; 128834-10-6P; 128834-11-7P; 128834-12-8P; 128900-00-5P; 128900-01-6P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and redn. of); 29802-24-2P; 85612-59-5P; 85612-60-8P; 104907-19-9P; 104907-20-2P; 104907-21-3P; 104907-22-4P; 104936-00-7P; 104975-45-3P; 105237-15-8P; 105469-09-8P; 125293-80-3P; 128636-12-4P; 128833-58-9P; 128833-59-0P; 128833-60-3P; 128833-61-4P; 128833-62-5P; 128833-64-7P; 128833-65-8P; 128833-66-9P; 128833-67-0P; 128833-68-1P; 128833-69-2P; 128833-70-5P; 128833-71-6P; 128833-72-7P; 128833-73-8P; 128833-74-9P; 128833-75-0P; 128833-76-1P; 128833-77-2P; 128833-78-3P; 128833-79-4P; 128833-80-7P; 128833-81-8P; 128833-82-9P; 128833-83-0P; 128833-84-1P; 128833-85-2P; 128833-86-3P; 128833-87-4P; 128833-89-6P; 128833-90-9P; 128833-91-0P; 128833-92-1P; 128833-93-2P; 28834-13-9P; 128834-14-0P; 128899-90-1P; 128899-91-2P; 128899-92-3P; 128899-93-4P; 128899-94-5P; 128899-95-6P; 128899-96-7P; 128899-97-8P; 128899-98-9P; 128899-99-0P; 128900-02-7P; 128900-03-8P; 176910-85-3P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 128610-22-0P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of reacmic); 74-89-5 (Methanamine) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with Me phenylalanine); 17193-31-6 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with formic acid and formaldehyde or acetone); 2577-90-4 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with methylamine); 10025-99-7 (Potassium tetrachloroplatinate(2-) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with substituted ethylenediamine); 75768-06-8 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction with hydrogen bromide and redn. of)
Institutionen:Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Schönenberger
Projekte:SFB 234
Identifikationsnummer:
WertTyp
1990:507966Andere
Stichwörter / Keywords:Neoplasm inhibitors (platinate chloro substituted-ethylendiamine complexes) Amino acids Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and esterification of, followed by amidation and redn.) platinate chloro substituted ethylenediamine antitumor activity platinate chloro substituted ethylenediamine amino acid esterification amination amino acid ester amide prepn redn
Dewey-Dezimal-Klassifikation:500 Naturwissenschaften und Mathematik > 540 Chemie
Status:Veröffentlicht
Begutachtet:Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:Ja
Eingebracht am:12 Nov 2010 07:24
Zuletzt geändert:12 Nov 2010 07:24
Dokumenten-ID:17679
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