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Synergism of lymphotoxin and interferon-gamma in the growth inhibition of breast cancer cell line MCF-7

Buck, C. and Wawer, A. and Mach, W. and Digel, W. and Otto, A. M. and Schönenberger, Helmut and Porzsolt, F. (1990) Synergism of lymphotoxin and interferon-gamma in the growth inhibition of breast cancer cell line MCF-7. In: Freund, M., (ed.) Cytokines in hemopoiesis, oncology, and AIDS. Springer, Berlin, pp. 205-210. ISBN 3-540-52281-6; 0-387-52281-6.

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Abstract

The effect was studied of recombinant lymphotoxin (rLT) in combination with interferons (rIFN-alpha , huIFN-beta , and rIFN-gamma ) on the proliferation of the breast cancer cell line MCF-7. Spontaneous [3H]thymidine incorporation of MCF-7 cells ranged up to 190,000 cmp after 72 h. The addn. of high doses of rLT (>100 U/mL) caused a significant growth inhibition, whereas low concns. (<20 U/mL) ...

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Item Type:Book Section
Date:1990
Additional information (public):CAN 115:253837 15-5 Immunochemistry
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1991:653837Other
Keywords:Carcinoma (of mammary gland, interferon and lymphotoxins effect on) Neoplasm inhibitors (carcinoma, interferons and lymphotoxins as, of mammary gland) Mammary gland (neoplasm, carcinoma, interferons and lymphotoxins effect on) Lymphokines and Cytokines Role: BIOL (Biological study) (tumor necrosis factor-beta , mammary gland carcinoma response to interferon and) Interferons Role: BIOL (Biological study) (gamma , mammary gland carcinoma response to lymphotoxin and) breast cancer inhibition interferon lymphotoxin mammary carcinoma inhibition interferon lymphotoxin
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:15 Nov 2010 14:52
Last Modified:15 Nov 2010 14:52
Item ID:17680
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