Buck, C. and Wawer, A. and Mach, W. and Digel, W. and Otto, A. M. and Schönenberger, Helmut and Porzsolt, F. (1990) Synergism of lymphotoxin and interferon-gamma in the growth inhibition of breast cancer cell line MCF-7. In: Freund, M., (ed.) Cytokines in hemopoiesis, oncology, and AIDS. Springer, Berlin, pp. 205-210. ISBN 3-540-52281-6; 0-387-52281-6.
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The effect was studied of recombinant lymphotoxin (rLT) in combination with interferons (rIFN-alpha , huIFN-beta , and rIFN-gamma ) on the proliferation of the breast cancer cell line MCF-7. Spontaneous [3H]thymidine incorporation of MCF-7 cells ranged up to 190,000 cmp after 72 h. The addn. of high doses of rLT (>100 U/mL) caused a significant growth inhibition, whereas low concns. (<20 U/mL) resulted only in a slight decrease of [3H]thymidine incorporation. Low concns. of both types interferons caused no growth inhibition. The combination of rLT (20 U/mL) and rIFN-gamma (20 U/mL) resulted in a synergistic redn. of [3H]thymidine incorporation, whereas the combination of rLT with rIFN-alpha or huIFN-beta caused only an additive growth inhibition. Thus, type II but not type I interferons cause a synergistic growth inhibition of the MCF-7 cell line.
|Item Type:||Book Section|
|Additional information (public):||CAN 115:253837 15-5 Immunochemistry|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Carcinoma (of mammary gland, interferon and lymphotoxins effect on) Neoplasm inhibitors (carcinoma, interferons and lymphotoxins as, of mammary gland) Mammary gland (neoplasm, carcinoma, interferons and lymphotoxins effect on) Lymphokines and Cytokines Role: BIOL (Biological study) (tumor necrosis factor-beta , mammary gland carcinoma response to interferon and) Interferons Role: BIOL (Biological study) (gamma , mammary gland carcinoma response to lymphotoxin and) breast cancer inhibition interferon lymphotoxin mammary carcinoma inhibition interferon lymphotoxin|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||15 Nov 2010 15:52|
|Last Modified:||15 Nov 2010 15:52|
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