Go to content
UR Home

Aqua[1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine](sulfato)platinum(II) complexes with variable substituents in the 2-phenyl ring. 1. Synthesis and antitumor and estrogenic properties

Gust, Ronald and Burgemeister, Thomas and Mannschreck, Albrecht and Schönenberger, Helmut (1990) Aqua[1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine](sulfato)platinum(II) complexes with variable substituents in the 2-phenyl ring. 1. Synthesis and antitumor and estrogenic properties. Journal of medicinal chemistry 33 (9), pp. 2535-2544.

Full text not available from this repository.


Abstract

Erythro- and threo-configurated PtL(H2O)(SO4) (L = 2,6-Cl2-4-HOC6H2CH2NH2CH2NH2R; R = Ph, 4-FC6H4, 3-HOC6H4, 4-HOC6H4, 2,6-F2C6H3, 2,6-Cl2C6H3, 2-F-4-HOC6H3, 2-Cl-4-HOC6H3) were synthesized and tested for estrogenic and antitumor activities. The ligands were obtained by a 3-step reaction. The stilbenes were reacted with a mixt. of ICl and NaN3 to yield the resp. 1,2-diazido-1,2-diphenylethanes. ...

plus


Export bibliographical data



Item Type:Article
Date:1990
Additional Information (public):CAN 113:105752 73-7 Optical, Electron, and Mass Spectroscopy and Other Related Properties 128413-06-9P; 128413-07-0P; 128413-08-1P; 128413-09-2P; 128413-10-5P; 128413-11-6P; 128413-12-7P; 128413-13-8P; 128524-07-2P; 128524-08-3P; 128524-09-4P; 128524-10-7P; 128524-11-8P; 128524-12-9P; 128524-13-0P; 128524-14-1P Role: PREP (Preparation) (prepn. and antitumor and estrogenic activity of); 128412-67-9P; 128412-68-0P; 128412-69-1P; 128412-70-4P; 128412-71-5P; 128412-72-6P; 128412-73-7P; 128412-74-8P; 128412-75-9P; 128412-76-0P; 128412-77-1P; 128412-78-2P; 128412-79-3P; 128412-80-6P; 128412-81-7P; 128444-65-5P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and estrogenic activity of); 128412-98-6P; 128412-99-7P; 128413-00-3P; 128413-01-4P; 128413-02-5P; 128413-03-6P; 128413-04-7P; 128413-05-8P; 128523-99-9P; 128524-00-5P; 128524-01-6P; 128524-02-7P; 128524-03-8P; 128524-04-9P; 128524-05-0P; 128524-06-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction of, with silver sulfate); 128412-82-8P; 128412-83-9P; 128412-84-0P; 128412-85-1P; 128412-86-2P; 128412-87-3P; 128412-88-4P; 128412-89-5P; 128412-90-8P; 128412-91-9P; 128444-64-4P; 128444-66-6P; 128444-67-7P; 128444-68-8P; 128444-69-9P; 128444-70-2P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and redn. of, by aluminohydride); 10025-99-7 (Dipotassium tetrachloroplatinate) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with iodide followed by reaction with (dichlorohydroxyphenyl)phenylethylenediamines); 128412-92-0; 128412-93-1; 128412-94-2; 128412-95-3; 128412-96-4; 128412-97-5; 128444-71-3; 128444-72-4 Role: RCT (Reactant), RACT (Reactant or reagent) (reactions of, with iodine chloride and sodium azide)
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Alumni or Retired Professors > Prof.Dr. Mannschreck
Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1990:505752Other
Keywords:Estrogens Role: PRP (Properties) ((dichlorohydroxyphenyl)phenylethylenediamines and their platinum sulfato complexes) Neoplasm inhibitors (platinum complexes with (dichlorohydroxyphenyl)phenylethylenediamines) antitumor activity platinum phenylethylenediamine complex estrogenic property platinum phenylethyleneidamine complex amine phenylethylenedi platinum complex
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Deposited On:12 Nov 2010 07:20
Last Modified:02 Dec 2010 08:42
Item ID:17681
Owner Only: item control page
  1. University

University Library

Publication Server

Contact person
Gernot Deinzer

Telefon 0941 943-2759
Contact