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Aqua[1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine](sulfato)platinum(II) complexes with variable substituents in the 2-phenyl ring. 1. Synthesis and antitumor and estrogenic properties

Gust, Ronald and Burgemeister, Thomas and Mannschreck, Albrecht and Schönenberger, Helmut (1990) Aqua[1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine](sulfato)platinum(II) complexes with variable substituents in the 2-phenyl ring. 1. Synthesis and antitumor and estrogenic properties. Journal of medicinal chemistry 33 (9), pp. 2535-2544.

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Abstract

Erythro- and threo-configurated PtL(H2O)(SO4) (L = 2,6-Cl2-4-HOC6H2CH2NH2CH2NH2R; R = Ph, 4-FC6H4, 3-HOC6H4, 4-HOC6H4, 2,6-F2C6H3, 2,6-Cl2C6H3, 2-F-4-HOC6H3, 2-Cl-4-HOC6H3) were synthesized and tested for estrogenic and antitumor activities. The ligands were obtained by a 3-step reaction. The stilbenes were reacted with a mixt. of ICl and NaN3 to yield the resp. 1,2-diazido-1,2-diphenylethanes. ...

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Item Type:Article
Date:1990
Additional information (public):CAN 113:105752 73-7 Optical, Electron, and Mass Spectroscopy and Other Related Properties 128413-06-9P; 128413-07-0P; 128413-08-1P; 128413-09-2P; 128413-10-5P; 128413-11-6P; 128413-12-7P; 128413-13-8P; 128524-07-2P; 128524-08-3P; 128524-09-4P; 128524-10-7P; 128524-11-8P; 128524-12-9P; 128524-13-0P; 128524-14-1P Role: PREP (Preparation) (prepn. and antitumor and estrogenic activity of); 128412-67-9P; 128412-68-0P; 128412-69-1P; 128412-70-4P; 128412-71-5P; 128412-72-6P; 128412-73-7P; 128412-74-8P; 128412-75-9P; 128412-76-0P; 128412-77-1P; 128412-78-2P; 128412-79-3P; 128412-80-6P; 128412-81-7P; 128444-65-5P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and estrogenic activity of); 128412-98-6P; 128412-99-7P; 128413-00-3P; 128413-01-4P; 128413-02-5P; 128413-03-6P; 128413-04-7P; 128413-05-8P; 128523-99-9P; 128524-00-5P; 128524-01-6P; 128524-02-7P; 128524-03-8P; 128524-04-9P; 128524-05-0P; 128524-06-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction of, with silver sulfate); 128412-82-8P; 128412-83-9P; 128412-84-0P; 128412-85-1P; 128412-86-2P; 128412-87-3P; 128412-88-4P; 128412-89-5P; 128412-90-8P; 128412-91-9P; 128444-64-4P; 128444-66-6P; 128444-67-7P; 128444-68-8P; 128444-69-9P; 128444-70-2P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and redn. of, by aluminohydride); 10025-99-7 (Dipotassium tetrachloroplatinate) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with iodide followed by reaction with (dichlorohydroxyphenyl)phenylethylenediamines); 128412-92-0; 128412-93-1; 128412-94-2; 128412-95-3; 128412-96-4; 128412-97-5; 128444-71-3; 128444-72-4 Role: RCT (Reactant), RACT (Reactant or reagent) (reactions of, with iodine chloride and sodium azide)
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Retired Professors > Prof.Dr. Mannschreck
Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1990:505752Other
Keywords:Estrogens Role: PRP (Properties) ((dichlorohydroxyphenyl)phenylethylenediamines and their platinum sulfato complexes) Neoplasm inhibitors (platinum complexes with (dichlorohydroxyphenyl)phenylethylenediamines) antitumor activity platinum phenylethylenediamine complex estrogenic property platinum phenylethyleneidamine complex amine phenylethylenedi platinum complex
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 07:20
Last Modified:02 Dec 2010 08:42
Item ID:17681
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