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Antiestrogenic N-(4-hydroxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-hydroxybenzamides: influence of hydrophobic groups substituted in the ortho position of the benzamide fragment on activity

Hartmann, Rolf W. and Vom Orde, Hans Dieter and Schönenberger, Helmut (1990) Antiestrogenic N-(4-hydroxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-hydroxybenzamides: influence of hydrophobic groups substituted in the ortho position of the benzamide fragment on activity. Archiv der Pharmazie 323 (2), pp. 73-78.

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Abstract

Title compds. I (R = R2 = H; R1 = Me, F, Cl, Br, CF3; R = H, R1 = R2 = Cl) were prepd. by acylating 4-MeOC6H4NMeCF3 with 2,6,4-R1R2(MeO)C6H2COCl (II) to give I (R = Me) and demethylating. II were obtained from 2,6,4-R1R2(MeO)C6H2Ac by NaOBr oxidn. I (R = R2 = H, R1 = Me, F) had true antiestrogenic activity and I (R = R2 = H, R1 = Cl) was a strong inhibitor of murine hormone-dependent mammary ...

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Item Type:Article
Date:1990
Additional information (public):CAN 113:23304 25-19 Benzene, Its Derivatives, and Condensed Benzenoid Compounds 117730-46-8 Role: RCT (Reactant), RACT (Reactant or reagent) (acylation of); 400-72-6 Role: RCT (Reactant), RACT (Reactant or reagent) (carboxylation of); 24826-74-2; 41068-36-4; 74457-86-6; 86111-47-9; 89691-67-8 Role: RCT (Reactant), RACT (Reactant or reagent) (oxidn. of); 127817-93-0P; 127817-94-1P; 127817-95-2P; 127817-96-3P; 127817-97-4P; 127851-72-3P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn. and antiestrogenic and antitumor activity of); 394-42-3P; 6245-57-4P; 21971-21-1P; 74317-85-4P; 94278-69-0P; 127817-85-0P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and chlorination of); 127817-87-2P; 127817-88-3P; 127817-89-4P; 127817-90-7P; 127817-91-8P; 127817-92-9P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and demethylation of); 321-24-4P; 31310-08-4P; 50424-99-2P; 88741-40-6P; 98187-17-8P; 127817-86-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction of, with trifluoropropylaniline)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1990:423304Other
Keywords:Neoplasm inhibitors ((hydroxyphenyl)(trifluoropropyl)hydroxybenzamides) Uterus ((hydroxyphenyl)(trifluoropropyl)hydroxybenzamides effect on) Estrogens Role: RCT (Reactant), RACT (Reactant or reagent) (antagonists, (hydroxyphenyl)(trifluoropropyl)hydroxybenzamides as) hydroxyphenylbenzamide prepn antiestrogenic antitumor uterus hydroxyphenylbenzamide prepn
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 07:18
Last Modified:12 Nov 2010 07:18
Item ID:17682
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