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Dissociation of estrogenic and cytotoxic properties of an estrogen receptor-binding platinum complex in human breast cancer cell lines

Otto, Angela M. and Faderl, Michael and Schönenberger, Helmut (1991) Dissociation of estrogenic and cytotoxic properties of an estrogen receptor-binding platinum complex in human breast cancer cell lines. Cancer research 51 (12), pp. 3217-3223.

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Abstract

The Pt complex [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]diaqua-Pt(II) sulfate (meso-6-PtSO4) was designed with the concept of combining the cytotoxic cisplatin with an estrogen receptor (ER)-binding ligand for targeting to ER+ mammary tumor cells. This Pt complex selectively inhibits growth of ER+ mammary tumors in rodents. To study the cellular mechanisms of action, cultures of ...

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Item Type:Article
Date:1991
Additional information (public):CAN 115:64205 1-6 Pharmacology 105856-32-4 Role: PRP (Properties) (antitumor effects of, mammary estrogen receptor binding in relation to)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1991:464205Other
Keywords:Receptors Role: BIOL (Biological study) (for estrogens, platinum complexes antitumor effects and binding to mammary) Neoplasm inhibitors (platinum complexes as, mammary estrogen receptor binding in relation to) Estrogens Role: BIOL (Biological study) (receptors for, platinum complexes antitumor effects and binding to mammary) Mammary gland (neoplasm, estrogen receptors of, platinum complexes cytotoxicity in relation to binding to) platinum complex antitumor mammary estrogen receptor
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 07:08
Last Modified:12 Nov 2010 07:08
Item ID:17690
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