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1,2-Diphenyl-1-pyridylbut-1-enes - potential antiestrogens. Part 2. Biological evaluation

Schwarz, Walter and Hartmann, Rolf W. and Schönenberger, Helmut (1991) 1,2-Diphenyl-1-pyridylbut-1-enes - potential antiestrogens. Part 2. Biological evaluation. Archiv der Pharmazie 324 (4), pp. 231-234.

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Abstract

Z-1-(4-Hydroxyphenyl)-1-(4- or 3-pyridyl)-2-phenylbut-1-enes and their acetates are weak estrogens (uterine wt. test, immature mouse), which cause a marked tumor growth inhibition on the hormone-dependent MXT mammary carcinoma of the mouse. Slight estrogenic side effects detd. by uterine wt. were detectable in this tumor ...

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Item Type:Article
Date:1991
Additional information (public):CAN 115:126496 1-6 Pharmacology 98540-29-5; 98540-30-8; 134242-15-2; 134242-16-3; 134242-17-4; 134242-18-5; 134242-19-6; 134242-20-9; 134242-21-0; 134242-23-2; 134242-24-3; 134242-25-4; 134264-49-6; 134955-53-6 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (antiestrogenic and antitumor activity of)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1991:526496Other
Keywords:Estrogens Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (diphenylpyridylbutenes as inhibitors of, antitumor activity of) Neoplasm inhibitors (diphenylpyridylbutenes as, antiestrogenic activity of) diphenylpyridylbutene estrogen pyridylbutene deriv antiestrogen antitumor butene deriv antiestrogen antitumor
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 07:06
Last Modified:12 Nov 2010 07:06
Item ID:17691
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