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Diamine ligand release from the cisplatin analog [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) in cell culture medium

Bednarski, Patrick J. and Truembach, Barbara and Kratochwil, Nicole A. and Schönenberger, Helmut (1992) Diamine ligand release from the cisplatin analog [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) in cell culture medium. Journal of medicinal chemistry 35 (23), pp. 4479-4485.

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Abstract

The stability of the five-membered chelate ring of the cisplatin analog [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) (I) was investigated under typical cell culture conditions (IMEM-Richter's medium with 10% fetal calf serum, 37 Deg). The platinum compd. was radiolabeled with tritium in the meta position of the arom. ring by an acid-catalyzed tritium-exchange ...

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Item Type:Article
Date:1992
Additional information (public):CAN 117:225633 1-1 Pharmacology 105856-23-3 Role: ANST (Analytical study) (diamine ligand release from, in cell culture medium); 143707-47-5P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and complexation of, with platinum); 143707-49-7P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and formation in cell culture medium of); 143707-46-4P; 143707-48-6P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 63-68-3 (Methionine) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with [bis(dichlorohydroxyphenyl)ethylenediamine]dichloroplatinum); 10025-99-7 (Dipotassium tetrachloroplatinate) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with bis(dichlorohydroxyphenyl)ethylenediamine); 111086-58-9 Role: PROC (Process) (release of, from platinum complex in cell culture medium)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1992:625633Other
Keywords:Animal tissue culture (diamine ligand release from cisplatin analog in) diamine ligand release cisplatin analog cell
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 07:00
Last Modified:12 Nov 2010 07:00
Item ID:17693
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