Otto, Angela M. and Bednarski, Patrick J. and Eggers, Hella and Truembach, Barbara and Schönenberger, Helmut (1992) [Meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)enthylenediamine] dichloroplatinum(II), an estrogenic platinum(II)-complex for the therapy of breast cancer: relationship between stability and effect. Pharmaceutical and pharmacological letters 1 (3), pp. 103-106.
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The inhibiting effect of [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) (meso-Pt(1)Cl2) (I) on the estrogen receptor-pos. (ER+) breast cancer in vivo is due to its cytotoxic as well as its estrogenic properties. In in vitro expts. on the ER+ MCF-7 breast cancer cell line meso-Pt(1)Cl2 can react with bionucleophils in cell culture medium, esp. with serum proteins, ...
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|Additional information (public):||CAN 117:204657 1-6 Pharmacology 105856-23-3 Role: BIOL (Biological study) (breast cancer inhibition by)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Neoplasm inhibitors (mammary gland, estrogenic platinum(II) complex as) Mammary gland (neoplasm, inhibitors, estrogenic platinum(II) complex as) estrogenic platinum complex breast cancer inhibitor|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||12 Nov 2010 06:56|
|Last Modified:||12 Nov 2010 06:56|