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[Meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)enthylenediamine] dichloroplatinum(II), an estrogenic platinum(II)-complex for the therapy of breast cancer: relationship between stability and effect

Otto, Angela M. and Bednarski, Patrick J. and Eggers, Hella and Truembach, Barbara and Schönenberger, Helmut (1992) [Meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)enthylenediamine] dichloroplatinum(II), an estrogenic platinum(II)-complex for the therapy of breast cancer: relationship between stability and effect. Pharmaceutical and pharmacological letters 1 (3), pp. 103-106.

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Abstract

The inhibiting effect of [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) (meso-Pt(1)Cl2) (I) on the estrogen receptor-pos. (ER+) breast cancer in vivo is due to its cytotoxic as well as its estrogenic properties. In in vitro expts. on the ER+ MCF-7 breast cancer cell line meso-Pt(1)Cl2 can react with bionucleophils in cell culture medium, esp. with serum proteins, ...

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Item Type:Article
Date:1992
Additional information (public):CAN 117:204657 1-6 Pharmacology 105856-23-3 Role: BIOL (Biological study) (breast cancer inhibition by)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1992:604657Other
Keywords:Neoplasm inhibitors (mammary gland, estrogenic platinum(II) complex as) Mammary gland (neoplasm, inhibitors, estrogenic platinum(II) complex as) estrogenic platinum complex breast cancer inhibitor
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 06:56
Last Modified:12 Nov 2010 06:56
Item ID:17695
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