Schertl, Sabine and Gust, Ronald and Müller, Richard and Spruss, Thilo and Schönenberger, Helmut (1992) Stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]platinum(II) complexes. Part III. Evaluation of the mammary tumor inhibiting properties. Archiv der Pharmazie 325 (2), pp. 113-118.
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Stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]platinum(II) complexes produce a strong configuration-dependent inhibition of the hormone sensitive MXT-mammary carcinoma of the mouse. Besides an interference in DNA synthesis analogous to that of cisplatin, an estrogen level lowering effect is responsible for its antitumor activity. The new complexes also show a significant activity on the hormone-independent MXT-mammary carcinoma of the mouse.
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|Additional Information (public):||CAN 116:187486 1-3 Pharmacology 93856-31-6; 106400-42-4 Role: BIOL (Biological study) (mammary tumor inhibition by racemic, structure in relation to); 93983-45-0; 105856-36-8; 119479-53-7; 119479-54-8 Role: BIOL (Biological study) (mammary tumor inhibition by, structure in relation to)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Neoplasm inhibitors (mammary gland, hydroxyphenylethylenediamineplatinum complexes as, structure-activity relationship of) Mammary gland (neoplasm, inhibitors, hydroxyphenylethylenediamineplatinum complexes as, structure-activity relationship of) Molecular structure-biological activity relationship (neoplasm-inhibiting, of hydroxyphenylethylenediamineplatinum complexes) hydroxyphenyl ethylenediamine platinum mammary tumor inhibitor|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||12 Nov 2010 06:54|
|Last Modified:||12 Nov 2010 06:54|