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Mammary tumor inhibiting [1,2-bis(2,6-dihalo-3-hydroxyphenyl)ethylenediamine]platinum(II) complexes. III. Relationship between structure and estrogenic activity of the diamine ligands, their sulfatoplatinum(II) and diiodoplatinum(II) complexes

Gust, Ronald and Schönenberger, Helmut (1993) Mammary tumor inhibiting [1,2-bis(2,6-dihalo-3-hydroxyphenyl)ethylenediamine]platinum(II) complexes. III. Relationship between structure and estrogenic activity of the diamine ligands, their sulfatoplatinum(II) and diiodoplatinum(II) complexes. Archiv der Pharmazie 326 (7), pp. 405-413.

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Abstract

1,2-Bis(2,6-dihalo-3-hydroxyphenyl)ethylenediamines with 2,6-Cl2, 2-F,6-Cl, 2-Cl,6-F, and 2,6-F2 substituents (meso-1 to meso-4, D,L-1 and D,L-4) and their sulfatoplatinum(II) complexes were tested in the immature mouse uterine wt. test. The only complex with marked estrogenic properties proved to be meso-1-PtSO4. Surprisingly its diamine ligand meso-1 was only marginally active. 1H-NMR ...

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Item Type:Article
Date:1993
Additional information (public):CAN 119:240909 1-3 Pharmacology 7440-06-4D (Platinum); 126735-37-3; 128413-03-6; 128413-11-6; 128413-12-7; 128413-13-8; 128524-04-9; 128524-12-9; 128524-13-0; 128524-14-1; 150390-74-2; 150447-55-5; 150448-26-3; 150520-05-1; 150520-06-2; 151037-67-1 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (estrogenic activity of, mammary antitumor activity in relation to); 150412-97-8 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (estrogenic activity of, structure in relation to)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1993:640909Other
Keywords:Conformation and Conformers (of hydroxyphenylethylenediamine sulfatoplatinum complexes) Molecular structure-biological activity relationship (estrogenic, of hydroxyphenylethylenediamine sulfatoplatinum complexes) Neoplasm inhibitors (mammary gland, hydroxyphenylethylenediamine sulfatoplatinum complexes as, estrogenic activity in, structure-activity relations of) Mammary gland (neoplasm, inhibitors, hydroxyphenylethylenediamine sulfatoplatinum complexes as, estrogenic activity in, structure-activity relations of) estrogenic platinum complex conformation
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 06:50
Last Modified:12 Nov 2010 06:50
Item ID:17698
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