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Breast cancer-inhibiting properties of leaving group derivatives of [1,2-bis(2,6-difluoro-3-hydroxyphenyl)ethylenediamine]platinum(II)

Gust, Ronald and Schönenberger, Helmut (1993) Breast cancer-inhibiting properties of leaving group derivatives of [1,2-bis(2,6-difluoro-3-hydroxyphenyl)ethylenediamine]platinum(II). European Journal of Medicinal Chemistry 28 (2), pp. 117-127.

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Abstract

Meso-PtLX2 (I; L = 1,2-bis(2,6-difluoro-3-hydroxyphenyl)ethylenediamine; X = 0.5SO4, NO3, PhSO3, cyclobutane-1,1-dicarboxylate (CBDC), isocitrate) and the 2 diastereomeric PtLCl2 were prepd. The influence of the leaving groups of I on several murine tumors: P388 leukemia, MTX-M3.2 breast cancer (hormone-sensitive) and MXT-Ovex breast cancer (hormone-insensitive) was studied. The compds. with ...

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Item Type:Article
Date:1993
Additional information (public):CAN 119:194326 78-7 Inorganic Chemicals and Reactions 14708-56-6 (Dipotassium tetraiodoplatinate(2-) Role: RCT (Reactant), RACT (Reactant or reagent) (complexation of, with bis(difluorohydroxyphenyl)ethylenediamine); 149949-23-5; 149949-24-6 Role: RCT (Reactant), RACT (Reactant or reagent) (complexation of, with platinum); 150390-77-5P; 150390-78-6P; 150567-36-5P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn. and mammary antitumor activity of); 150447-56-6P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and mammary antitumor activity of racemic); 150390-74-2P; 150390-75-3P; 150390-76-4P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn. and metathesis and mammary antitumor activity of); 150447-55-5P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and metathesis and mammary antitumor activity of racemic); 150390-73-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and metathesis of); 150447-54-4P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and metathesis of racemic)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1993:594326Other
Keywords:Neoplasm inhibitors (platinum bis(difluorohydroxyphenyl)ethylenediamine complexes, toward mammary tumors) Isomerism and Isomers (diastereo-, of platinum bis(difluorohydroxyphenyl)ethylenediamine complexes) antitumor agent platinum hydroxyphenylethylenediamine complex amine hydroxyphenylethylenedi platinum complex
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 06:49
Last Modified:12 Nov 2010 06:49
Item ID:17699
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