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Aqua[1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine]sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring. II. Correlation of molecular structure and estrogenic activity of breast and prostate cancer inhibiting [erythro-1-(2,6-dichloro-4-hydroxyphenyl)-2-(2-halo-4-hydroxyphenyl)ethylenediamine]platinum(II) complexes

Gust, Ronald and Schönenberger, Helmut and Klement, Ulrich and Range, Klaus Juergen (1993) Aqua[1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine]sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring. II. Correlation of molecular structure and estrogenic activity of breast and prostate cancer inhibiting [erythro-1-(2,6-dichloro-4-hydroxyphenyl)-2-(2-halo-4-hydroxyphenyl)ethylenediamine]platinum(II) complexes. Archiv der Pharmazie 326 (12), pp. 967-976.

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Abstract

Complete three-dimensional x-ray crystal structure analyses of estrogenic [erythro-1-(2,6-dichloro-4-hydroxyphenyl)-2-(2-halo-4-hydroxyphenyl)ethylenediamine]diiodoplatinum(II) complexes [halo = fluoro:erythro-8-PtI2 (I) and halo = chloro:erythro-9-PtI2 (II)] which were synthesized for application in breast and prostate cancer, have been carried out. The 6239 as well as the 6521 reflexes were ...

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Item Type:Article
Date:1993
Additional information (public):CAN 120:182470 1-6 Pharmacology 128413-04-7; 128413-05-8 Role: BIOL (Biological study) (crystal structure of and estrogenic activity of, cancer inhibition in relation to); 111112-54-0; 153697-92-8; 153697-93-9; 153697-94-0; 153697-95-1 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (estrogenic activity of, structure in relation to)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1994:182470Other
Keywords:Estrogens Role: BIOL (Biological study) ([(hydroxyphenyl)ethylenediamine]platinum(II) complexes as, structure in relation to) Conformation and Conformers (of [(halohydroxyphenyl)ethylenediamine]platinum(II) complexes) Crystal structure (of [(halohydroxyphenyl)ethylenediamine]platinum(II) complexes, estrogenicity in relation to) Molecular structure-biological activity relationship (estrogenic, of [(hydroxyphenyl)ethylenediamine]platinum(II) complexes) Neoplasm inhibitors (mammary gland, [(hydroxyphenyl)ethylenediamine]platinum(II) complexes as, estrogenic activity in relation to) Mammary gland Prostate gland (neoplasm, inhibitors, [(hydroxyphenyl)ethylenediamine]platinum(II) complexes as, estrogenic activity in relation to) Neoplasm inhibitors (prostate gland, [(hydroxyphenyl)ethylenediamine]platinum(II) complexes as, estrogenic activity in relation to) phenylethylenediamine platinum complex estrogenic crystal structure conformation phenylethylenediamine platinum complex estrogenic activity mammary cancer inhibitor phenylethylenediamine platinum complex
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 06:47
Last Modified:12 Nov 2010 06:47
Item ID:17700
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