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[Meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine] -dichloroplatinum(II), a new drug not only parenterally but also orally active in the therapy of breast and prostate cancer

Spruss, Thilo and Schertl, Sabine and Schneider, Martin R. and Gust, Ronald and Bauer, Kurt and Schönenberger, Helmut (1993) [Meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine] -dichloroplatinum(II), a new drug not only parenterally but also orally active in the therapy of breast and prostate cancer. Journal of cancer research and clinical oncology 119 (12), pp. 707-716.

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Abstract

The platinum complex [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)- ethylenediamine]dichloroplatnum(II), K, was tested for its antitumor activity on hormone-sensitive tumor models under peroral administration. The resorption from the gastrointestinal tract was proved by detg. the estrogenic effect of K in a dose/activity study using the immature-mouse uterine wt. test. In comparison to the s.c. ...

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Item Type:Article
Date:1993
Additional information (public):CAN 120:260726 1-6 Pharmacology 105856-23-3; 111086-58-9 Role: BIOL (Biological study) (breast and prostate cancer inhibition by); 15663-27-1 (Cisplatin) Role: BIOL (Biological study) (breast and prostate cancer inhibition by mesodichlorohydroxyphenylethylenediaminedichloroplatinum(II) vs.)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1994:260726Other
Keywords:Neoplasm inhibitors (mammary gland, orally active mesodichlorohydroxyphenylethylenediaminedichloroplatinum(II) Mammary gland Prostate gland (neoplasm, inhibitors, orally active mesodichlorohydroxyphenylethylenediaminedichloroplatinum(II) Neoplasm inhibitors (prostate gland, orally active mesodichlorohydroxyphenylethylenediaminedichloroplatinum(II) platinum complex antitumor breast prostate cancer
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:10 Nov 2010 12:06
Last Modified:12 Nov 2010 06:21
Item ID:17703
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