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Reduction of the estrogenic side effects of the mammary tumor-inhibiting drug [1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) by variation of ring substituents

Gust, Ronald und Karl, Johann und Faderl, Michael und Schönenberger, Helmut (1995) Reduction of the estrogenic side effects of the mammary tumor-inhibiting drug [1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) by variation of ring substituents. Archiv der Pharmazie 328 (5), S. 457-463.

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Zusammenfassung

[1,2-Bis(4-methoxy/4-hydroxyphenyl)ethylenediamine]dichloroplatinum-(II) complexes were tested on the MDA-MB 231 breast cancer cell line, the lymphocytic leukemia P388, and the estrogen receptor-pos. and -neg. MXT mammary carcinoma of the mouse (MXT,ER(+)-MC, MXT,ER(-)-MC). The comparison of the effects of methoxy-substituted complexes with those of the resp. hydroxy-substituted ones shows that a ...

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Dokumentenart:Artikel
Datum:1995
Zusätzliche Informationen (Öffentlich):CAN 123:74226 1-3 Pharmacology 105855-87-6; 105856-21-1; 105856-22-2; 105856-23-3; 105928-14-1; 105990-36-1; 165289-81-6 Role: BAC (Biological activity or effector, except adverse), BPR (Biological process), BSU (Biological study, unclassified), PRP (Properties), THU (Therapeutic use), BIOL (Biological study), PROC (Process), USES (Uses) (redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) by variation of ring substituents); 10025-99-7; 111112-21-1 Role: RCT (Reactant), RACT (Reactant or reagent) (redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) by variation of ring substituents)
Institutionen:Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Schönenberger
Projekte:SFB 234
Identifikationsnummer:
WertTyp
1995:609517Andere
Stichwörter / Keywords:Conformation and Conformers (redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) by variation of ring substituents) Estrogen receptors Role: BPR (Biological process), BSU (Biological study, unclassified), BIOL (Biological study), PROC (Process) (redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) Estrogens Role: BSU (Biological study, unclassified), BIOL (Biological study) (redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) by variation of ring substituents) Receptors Role: BPR (Biological process), BSU (Biological study, unclassified), BIOL (Biological study), PROC (Process) (estrogen, redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) Molecular structure-biological activity relationship (estrogenic, redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) by variation of ring substituents) Neoplasm inhibitors (mammary gland, redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) by variation of ring substituents) Mammary gland (neoplasm, inhibitors, redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) by variation of ring substituents) Molecular structure-biological activity relationship (neoplasm-inhibiting, redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) by variation of ring substituents) phenylethyleneamine platinum complex mammary antitumor estrogenic mammary cancer inhibitor phenylethyleneamine platinum complex
Dewey-Dezimal-Klassifikation:500 Naturwissenschaften und Mathematik > 540 Chemie
Status:Veröffentlicht
Begutachtet:Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:Ja
Eingebracht am:10 Nov 2010 12:01
Zuletzt geändert:12 Nov 2010 06:23
Dokumenten-ID:17706
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