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Investigation of the Configurational and Conformational Influences on the Hormonal Activity of 1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their Platinum(II) Complexes. 1. Synthesis, Estradiol Receptor Affinity, and Estrogenic Activity of Diastereomeric [N-Alkyl- and N,N'-Dialkyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) Complexes

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (1995) Investigation of the Configurational and Conformational Influences on the Hormonal Activity of 1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their Platinum(II) Complexes. 1. Synthesis, Estradiol Receptor Affinity, and Estrogenic Activity of Diastereomeric [N-Alkyl- and N,N'-Dialkyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) Complexes. Journal of Medicinal Chemistry 38 (12), pp. 2070-2079.

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Abstract

N-Monoalkylated (Et) and N,N'-dialkylated (Me and Et) 1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and their dichloroplatinum(II) complexes were synthesized, and their configuration and conformational behavior were 1H-NMR spectroscopically clarified. The latter was brought in relation to their relative binding affinity (RBA) to the estrogen receptor as well as to their estrogenic ...

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Item Type:Article
Date:1995
Additional information (public):CAN 123:46660 78-7 Inorganic Chemicals and Reactions 10025-99-7 (Potassium tetrachloroplatinate(2-); 83363-98-8; 164411-34-1 Role: RCT (Reactant), RACT (Reactant or reagent) (for prepn. of platinum(II) chloro bis(dichlorohydroxyphenyl)ethylenediamine complex); 164411-32-9P; 164411-33-0P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (for prepn. of platinum(II) chloro bis(dichlorohydroxyphenyl)ethylenediamine complex); 105856-23-3; 105928-14-1; 111086-58-9; 111112-21-1 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (prepn., estradiol receptor affinity, and estrogenic activity of diastereomeric platinum(II) chloro bis(dichlorohydroxyphenyl)ethylenediamine complexes); 82772-86-9P; 82772-87-0P; 82772-89-2P; 82772-90-5P; 164411-30-7P; 164411-31-8P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), RCT (Reactant), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation), RACT (Reactant or reagent) (prepn., estradiol receptor affinity, and estrogenic activity of diastereomeric platinum(II) chloro bis(dichlorohydroxyphenyl)ethylenediamine complexes); 164411-28-3P; 164411-29-4P; 164577-11-1P; 164577-12-2P; 164577-13-3P; 164577-14-4P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn., estradiol receptor affinity, and estrogenic activity of diastereomeric platinum(II) chloro bis(dichlorohydroxyphenyl)ethylenediamine complexes)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1995:591763Other
Keywords:Configuration Conformation and Conformers (prepn., estradiol receptor affinity, and estrogenic activity of diastereomeric platinum(II) chloro bis(dichlorohydroxyphenyl)ethylenediamine complexes) Estrogens Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (prepn., estradiol receptor affinity, and estrogenic activity of diastereomeric platinum(II) chloro bis(dichlorohydroxyp Estrogen receptors Role: BSU (Biological study, unclassified), BIOL (Biological study) (prepn., estradiol receptor affinity, and estrogenic activity of diastereomeric platinum(II) chloro bis(dichlorohydroxyphenyl)ethylenediamine complexes) Receptors Role: BSU (Biological study, unclassified), BIOL (Biological study) (estrogen, prepn., estradiol receptor affinity, and estrogenic activity of diastereomeric platinum(II) chloro bis(dichlorohydroxyphenyl)ethylenediamine complexes) Molecular structure-biological activity relationship (estrogen receptor-binding, prepn., estradiol receptor affinity, and estrogenic activity of diastereomeric platinum(II) chloro bis(dichlorohydroxyphenyl)ethylenediamine complexes) platinum chloro hydroxyphenylethylenediamine estrogen receptor binding ethylenediamine deriv platinum complex estrogen activity
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:10 Nov 2010 11:58
Last Modified:12 Nov 2010 06:23
Item ID:17707
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