Startseite UR

Breast cancer inhibiting diastereomeric diacetato[1,2-bis(4-fluorophenyl)ethylenediamine]platinum(II) derivatives: synthesis and studies on the relationship between reactivity and antitumor activity

Gust, Ronald und Krauser, Rudolf und Schmid, Beate und Schönenberger, Helmut (1996) Breast cancer inhibiting diastereomeric diacetato[1,2-bis(4-fluorophenyl)ethylenediamine]platinum(II) derivatives: synthesis and studies on the relationship between reactivity and antitumor activity. Inorganica chimica acta 250 (1-2), S. 203-218.

Im Publikationsserver gibt es leider keinen Volltext zu diesem Eintrag.


Zusammenfassung

Antitumor active [1,2-bis(4-fluorophenyl)ethylenediamine]platinum(II) diastereoisomers contg. HOAc derivs. as 'leaving groups' (acetate: meso/rac-4F-Pt(Ac)2; monochloroacetate: meso/rac-4F-Pt(ClAc)2; dichloroacetate: meso/rac-4F-Pt(Cl2Ac)2; trichloroacetate: meso/rac-4F-Pt(Cl3Ac)2; glycolate: meso/rac-4F-Pt(OHAc)2; phenylacetate: meso/rac-4F-Pt(PhAc)2) were synthesized and characterized by IR and ...

plus


Bibliographische Daten exportieren



Dokumentenart:Artikel
Datum:1996
Zusätzliche Informationen (Öffentlich):CAN 126:69235 78-7 Inorganic Chemicals and Reactions 105856-26-6 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (cytotoxicity for breast cancer); 184895-34-9; 185069-15-2 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), RCT (Reactant), BIOL (Biological study), RACT (Reactant or reagent) (cytotoxicity for breast cancer and reaction with acetic acid or its derivs.); 65-85-0 (Benzoic acid); 76-03-9 (Trichloroacetic acid); 79-11-8 (Monochloroacetic acid); 79-14-1; 79-43-6 (Dichloroacetic acid) Role: RCT (Reactant), RACT (Reactant or reagent) (for prepn. of platinum bis(fluorophenyl)ethylenediamine acetate complex); 105990-74-7 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), PRP (Properties), RCT (Reactant), BIOL (Biological study), RACT (Reactant or reagent) (kinetics of iodide substitution and cytotoxicity for breast cancer); 184895-28-1P; 184895-29-2P; 184895-30-5P; 184895-31-6P; 184895-32-7P; 184895-33-8P; 185069-09-4P; 185069-10-7P; 185069-11-8P; 185069-12-9P; 185069-13-0P; 185069-14-1P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), PRP (Properties), RCT (Reactant), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation), RACT (Reactant or reagent) (prepn., kinetics of substitution and breast cancer cytotoxicity of platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes)
Institutionen:Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Schönenberger
Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische / Medizinische Chemie II (Prof. Buschauer)
Projekte:SFB 234
Identifikationsnummer:
WertTyp
1996:700389Andere
Stichwörter / Keywords:Hydrolysis kinetics (of platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes) Substituent effects (of platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes vs. breast cancer cytotoxicity) Substitution reaction kinetics (of platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes with iodide) Antitumor agents (platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes as) platinum bisfluorophenylethylenediamine acetate deriv prepn cytotoxicity fluorophenylethylenediamine platinum acetate deriv prepn cytotoxicity cytotoxicity platinum bisfluorophenylethylenediamine acetate deriv substituent kinetics substitution platinum bisfluorophenylethylenediamine acetate deriv breast cancer cytotoxicity platinum bisfluorophenylethylenediamine acetate diastereoisomer platinum bisfluorophenylethylenediamine acetate prepn cytotoxicity
Dewey-Dezimal-Klassifikation:500 Naturwissenschaften und Mathematik > 540 Chemie
Status:Veröffentlicht
Begutachtet:Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:Ja
Eingebracht am:10 Nov 2010 11:54
Zuletzt geändert:10 Nov 2010 11:59
Dokumenten-ID:17711
Nur für Besitzer und Autoren: Kontrollseite des Eintrags
  1. Universität

Universitätsbibliothek

Publikationsserver

Kontakt:

Publizieren: oa@ur.de

Dissertationen: dissertationen@ur.de

Forschungsdaten: daten@ur.de

Ansprechpartner