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Breast cancer inhibiting diastereomeric diacetato[1,2-bis(4-fluorophenyl)ethylenediamine]platinum(II) derivatives: synthesis and studies on the relationship between reactivity and antitumor activity

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1996) Breast cancer inhibiting diastereomeric diacetato[1,2-bis(4-fluorophenyl)ethylenediamine]platinum(II) derivatives: synthesis and studies on the relationship between reactivity and antitumor activity. Inorganica chimica acta 250 (1-2), pp. 203-218.

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Abstract

Antitumor active [1,2-bis(4-fluorophenyl)ethylenediamine]platinum(II) diastereoisomers contg. HOAc derivs. as 'leaving groups' (acetate: meso/rac-4F-Pt(Ac)2; monochloroacetate: meso/rac-4F-Pt(ClAc)2; dichloroacetate: meso/rac-4F-Pt(Cl2Ac)2; trichloroacetate: meso/rac-4F-Pt(Cl3Ac)2; glycolate: meso/rac-4F-Pt(OHAc)2; phenylacetate: meso/rac-4F-Pt(PhAc)2) were synthesized and characterized by IR and ...

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Item Type:Article
Date:1996
Additional information (public):CAN 126:69235 78-7 Inorganic Chemicals and Reactions 105856-26-6 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (cytotoxicity for breast cancer); 184895-34-9; 185069-15-2 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), RCT (Reactant), BIOL (Biological study), RACT (Reactant or reagent) (cytotoxicity for breast cancer and reaction with acetic acid or its derivs.); 65-85-0 (Benzoic acid); 76-03-9 (Trichloroacetic acid); 79-11-8 (Monochloroacetic acid); 79-14-1; 79-43-6 (Dichloroacetic acid) Role: RCT (Reactant), RACT (Reactant or reagent) (for prepn. of platinum bis(fluorophenyl)ethylenediamine acetate complex); 105990-74-7 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), PRP (Properties), RCT (Reactant), BIOL (Biological study), RACT (Reactant or reagent) (kinetics of iodide substitution and cytotoxicity for breast cancer); 184895-28-1P; 184895-29-2P; 184895-30-5P; 184895-31-6P; 184895-32-7P; 184895-33-8P; 185069-09-4P; 185069-10-7P; 185069-11-8P; 185069-12-9P; 185069-13-0P; 185069-14-1P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), PRP (Properties), RCT (Reactant), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation), RACT (Reactant or reagent) (prepn., kinetics of substitution and breast cancer cytotoxicity of platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
1996:700389Other
Keywords:Hydrolysis kinetics (of platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes) Substituent effects (of platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes vs. breast cancer cytotoxicity) Substitution reaction kinetics (of platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes with iodide) Antitumor agents (platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes as) platinum bisfluorophenylethylenediamine acetate deriv prepn cytotoxicity fluorophenylethylenediamine platinum acetate deriv prepn cytotoxicity cytotoxicity platinum bisfluorophenylethylenediamine acetate deriv substituent kinetics substitution platinum bisfluorophenylethylenediamine acetate deriv breast cancer cytotoxicity platinum bisfluorophenylethylenediamine acetate diastereoisomer platinum bisfluorophenylethylenediamine acetate prepn cytotoxicity
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:10 Nov 2010 11:54
Last Modified:10 Nov 2010 11:59
Item ID:17711
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