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Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

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Abstract

The synthesis of the diastereomeric [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes, rac- and meso-4F-Pt(X) [X = oxalato (Ox), malonato (Mal), hydroxymalonato (OHMal), phenylmalonato (PhMal), tetrahydro-4H-pyran-4,4-dicarboxylato (Thpdc)], the evaluation of their structure, water soly., resistance against attack by nucleophiles, and growth inhibiting properties on ...

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Item Type:Article
Date:1998
Additional information (public):CAN 128:162186 78-7 Inorganic Chemicals and Reactions 80-69-3 (Hydroxymalonic acid); 141-82-2 (Malonic acid); 144-62-7 (Oxalic acid); 2613-89-0 (Phenylmalonic acid); 5337-04-2 (Tetrahydro-4H-pyran-4,4-dicarboxylic acid); 184895-34-9; 185069-15-2 Role: RCT (Reactant), RACT (Reactant or reagent) (for prepn. of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes); 7681-11-0 (Potassium iodide) Role: PEP (Physical, engineering or chemical process), PROC (Process) (kinetics of nucleophilic substitution by I- of platinum fluorophenylethylenediamine dicarboxylato complexes); 202755-80-4P; 202755-81-5P; 202755-82-6P; 202755-83-7P; 202755-84-8P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), PRP (Properties), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn., water soly., and antitumor activity against human MCF-7 breast cancer); 202646-08-0P; 202646-09-1P; 202646-10-4P; 202646-11-5P; 202646-12-6P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), PRP (Properties), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn., water soly., antitumor activity against human MCF-7 breast cancer, and kinetics of nucleophilic substitution by I-)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
1998:89683Other
Keywords:Transition metal complexes Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), PRP (Properties), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (carboxylic acid, platinum prepn., water soly., and antitumor activity against human MCF-7 breast cancer of fluorophenyl ethylenediamine dicarboxylato Pt complexes) Antitumor agents (mammary gland prepn. and antitumor activity of platinum fluorophenylethylenediamine dicarboxylato complexes) Mammary gland (neoplasm, inhibitors prepn. and antitumor activity of platinum fluorophenylethylenediamine dicarboxylato complexes) Substitution reaction kinetics (nucleophilic of platinum fluorophenylethylenediamine dicarboxylato complexes with iodide) Carboxylic acids Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), PRP (Properties), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (transition metal complexes, platinum prepn., water soly., and antitumor activity against human MCF-7 breast cancer of fluorophenyl ethylenediamine dicarboxylato Pt complexes) Solubility (water soly. of platinum fluorophenylethylenediamine dicarboxylato complexes) fluorophenylethylenediamine dicarboxylato platinum complex prepn antitumor activity platinum fluorophenylethylenediamine dicarboxylato complex soly fluorophenylethylenediamine dicarboxylato platinum complex nucleophilic substitution kinetics fluorophenylethylenediamine dicarboxylatoplatinum complex
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:09 Nov 2010 14:18
Last Modified:09 Nov 2010 14:23
Item ID:17718
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