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[Meso- and rac-1,2-bis(4-fluorophenyl)ethylenediamine]chloro[sulfinylbis(methane)-S]platinum(II) chloride new water soluble platinum complexes with high anti-breast cancer activities

Gust, Ronald and Heinrich, Heike and Krauser, Rudolf and Schönenberger, Helmut (1999) [Meso- and rac-1,2-bis(4-fluorophenyl)ethylenediamine]chloro[sulfinylbis(methane)-S]platinum(II) chloride new water soluble platinum complexes with high anti-breast cancer activities. Inorganica chimica acta 285 (2), pp. 184-189.

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Abstract

The synthesis, the physicochem. and the breast cancer inhibiting properties of [meso- and rac-1,2-bis(4-fluorophenyl)ethylenediamine]chloro[sulfinylbis(methane)-S]platinum(II) chlorides (meso- and rac-4F-PtCl(DMSO)) are described. Rac-4F-PtCl(DMSO) surpasses the std. carboplatin in its effect on the human MCF-7 breast cancer cell line and is more resistant than its dichloroplatinum(II) analog rac-4F-PtCl2 against attack of nucleophiles, a prerequisite for sufficient stability in physiol. environments and consequently for marked antitumor activity in vivo.

Item Type:

Article

Additional information (public):

CAN 130:261019 78-7 Inorganic Chemicals and Reactions 221619-05-2; 221619-08-5 Role: FMU (Formation, unclassified), FORM (Formation, nonpreparative) (formation from chloride analog); 221619-01-8P Role: SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. as breast tumor inhibitors); 221648-13-1P Role: RCT (Reactant), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses), RACT (Reactant or reagent) (prepn. as breast tumor inhibitors and substitution with iodide); 67-68-5 (DMSO); 118097-81-7; 118141-52-9 Role: RCT (Reactant), RACT (Reactant or reagent) (reactant for prepn. of platinum bis(fluorophenyl)ethylenediamine DMSO complexes)

Institutions:

Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)

Projects:

SFB 234

Identification Number:

Value	Type
1999:141478	Other

Keywords:

Antitumor agents (mammary gland platinum bis(fluorophenyl)ethylenediamine DMSO complexes as) Mammary gland (neoplasm, inhibitors platinum bis(fluorophenyl)ethylenediamine DMSO complexes as) platinum fluorophenylethylenediamine DMSO prepn breast antitumor agent

Subjects:

500 Science > 540 Chemistry & allied sciences

Status:

Published

Refereed:

Yes, this version has been refereed

Created at the University of Regensburg:

Yes

Owner:

Petra Gürster

Deposited On:

09 Nov 2010 15:16