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[Meso- and rac-1,2-bis(4-fluorophenyl)ethylenediamine]chloro[sulfinylbis(methane)-S]platinum(II) chloride new water soluble platinum complexes with high anti-breast cancer activities

Gust, Ronald and Heinrich, Heike and Krauser, Rudolf and Schönenberger, Helmut (1999) [Meso- and rac-1,2-bis(4-fluorophenyl)ethylenediamine]chloro[sulfinylbis(methane)-S]platinum(II) chloride new water soluble platinum complexes with high anti-breast cancer activities. Inorganica chimica acta 285 (2), pp. 184-189.

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Abstract

The synthesis, the physicochem. and the breast cancer inhibiting properties of [meso- and rac-1,2-bis(4-fluorophenyl)ethylenediamine]chloro[sulfinylbis(methane)-S]platinum(II) chlorides (meso- and rac-4F-PtCl(DMSO)) are described. Rac-4F-PtCl(DMSO) surpasses the std. carboplatin in its effect on the human MCF-7 breast cancer cell line and is more resistant than its dichloroplatinum(II) analog ...

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Item Type:Article
Date:1999
Additional information (public):CAN 130:261019 78-7 Inorganic Chemicals and Reactions 221619-05-2; 221619-08-5 Role: FMU (Formation, unclassified), FORM (Formation, nonpreparative) (formation from chloride analog); 221619-01-8P Role: SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. as breast tumor inhibitors); 221648-13-1P Role: RCT (Reactant), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses), RACT (Reactant or reagent) (prepn. as breast tumor inhibitors and substitution with iodide); 67-68-5 (DMSO); 118097-81-7; 118141-52-9 Role: RCT (Reactant), RACT (Reactant or reagent) (reactant for prepn. of platinum bis(fluorophenyl)ethylenediamine DMSO complexes)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
1999:141478Other
Keywords:Antitumor agents (mammary gland platinum bis(fluorophenyl)ethylenediamine DMSO complexes as) Mammary gland (neoplasm, inhibitors platinum bis(fluorophenyl)ethylenediamine DMSO complexes as) platinum fluorophenylethylenediamine DMSO prepn breast antitumor agent
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:09 Nov 2010 14:16
Last Modified:09 Nov 2010 14:24
Item ID:17719
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