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[Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

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Abstract

In the search for new anti-breast cancer compds. a series of diastereomeric aqua[1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine]sulfatoplatinum(II) complexes was tested on the hormone-sensitive MXT-M-3.2 breast cancer of the mouse. By simultaneous detn. of tumor and uterine wts. at the end of the expt. the authors obtained an insight into the mode of action. Changes in the uterine wts. ...

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Item Type:Article
Date:2000
Additional information (public):CAN 135:40383 1-3 Pharmacology 126735-37-3; 128413-06-9; 128413-07-0; 128413-08-1; 128413-09-2; 128413-10-5; 128413-11-6; 128413-12-7; 128413-13-8; 128524-07-2; 128524-08-3; 128524-09-4; 128524-10-7; 128524-11-8; 128524-12-9; 128524-13-0; 128524-14-1 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), PRP (Properties), THU (Therapeutic use), BIOL (Biological study), USES (Uses) ([Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
2000:710098Other
Keywords:DNA formation ([Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties) Estrogens Role: BAC (Biological activity or effector, except adverse), BPR (Biological process), BSU (Biological study, unclassified), MFM (Metabolic formation), BIOL (Biological study), FORM (Formation, nonpreparative), PROC (Process) ([Aqua-1-(2,6-dic Structure-activity relationship (antitumor [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties) Antitumor agents (mammary gland [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties) Mammary gland (neoplasm, inhibitors [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties) antitumor breast phenylethylenediamine platinum complex
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:09 Nov 2010 14:14
Last Modified:09 Nov 2010 14:24
Item ID:17720
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