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Impact of normothermic perfusion and protein supplementation on human endothelial cell function during organ preservation

Puehler, Thomas and Gleich, Otto and Schopka, Simon and Rupprecht, Leopold and Hirt, Stephan and Schmid, Christof and Lehle, Karla (2010) Impact of normothermic perfusion and protein supplementation on human endothelial cell function during organ preservation. The Annals of thoracic surgery 89 (2), pp. 512-520.

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Abstract

BACKGROUND: Hypothermia-induced changes in endothelial cell (EC) morphology and function after organ storage may influence the initial outcome and development of transplant-associated coronary artery disease. METHODS: Human saphenous vein ECs were incubated with saline (NaCl), University of Wisconsin (UW), and histidine-tryptophan-ketoglutarate (HTK) solution, with and without protein additives, ...

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Item Type:Article
Date:2010
Institutions:Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie
Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde
Identification Number:
ValueType
20103335PubMed ID
10.1016/j.athoracsur.2009.10.037DOI
Classification:
NotationType
AdenosineMESH
Adenosine Triphosphate/metabolismMESH
AllopurinolMESH
Apoptosis/physiologyMESH
Blood Proteins/pharmacologyMESH
Cell Adhesion/physiologyMESH
Cell CountMESH
Cell Survival/physiologyMESH
CryopreservationMESH
E-Selectin/metabolismMESH
Endothelial Cells/physiologyMESH
Energy Metabolism/physiologyMESH
GlucoseMESH
GlutathioneMESH
HumansMESH
InsulinMESH
MannitolMESH
Mitochondria/physiologyMESH
Organ Preservation/methodsMESH
Organ Preservation SolutionsMESH
PerfusionMESH
Potassium ChlorideMESH
ProcaineMESH
RaffinoseMESH
Sodium ChlorideMESH
Warm IschemiaMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Otto Gleich
Deposited On:03 Nov 2010 07:01
Last Modified:03 Nov 2010 07:01
Item ID:17745
Owner Only: item control page
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