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Molecular analysis of the interaction of the four histamine receptor subtypes with antidepressant and antipsychotic drugs

URN to cite this document: urn:nbn:de:bvb:355-epub-178244

Appl, Heidrun (2010) Molecular analysis of the interaction of the four histamine receptor subtypes with antidepressant and antipsychotic drugs. PhD, Universität Regensburg

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Abstract (English)

Antidepressant and antipsychotic drugs are known to affect multiple molecular targets. Beside their determinant effects on the neurotransmission of serotonin, norepinephrine and dopamine via several transporters and receptors, they may also modulate muscarinic acetylcholine receptors and the histamine H1 receptor (H1R). Consequently, these drugs do not only yield unique profiles of desired ...

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Translation of the abstract (German)

Antidepressiva und Neuroleptika entfalten ihre spezifischen Wirkungen durch Interaktionen mit zahlreichen Zielstrukturen. Neben den Wirkungen auf die serotonerge, noradrenerge und dopaminerge Neurotransmission durch verschiedene Transporter und Rezeptoren interagieren sie ebenso mit muskarinischen Acetylcholin-Rezeptoren und dem Histamin H1 Rezeptor (H1R). Infolgedessen zeichnen sich diese ...

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Export bibliographical data

Item Type:Thesis of the University of Regensburg (PhD)
Date:26 November 2010
Referee:Prof. Dr. Roland Seifert and Prof. Dr. Dr. Ekkehard Haen
Date of exam:29 October 2010
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Research groups and research centres:Not selected
Keywords:Histamin, G-Protein gekoppelter Rezeptor, Radioaktivität, Molekulare Pharmakologie, Psychopharmaka, Antidepressiva, Neuroleptika, Plasmakonzentration, therapeutischer Referenzbereich; histamine, G protein-coupled receptor, radioactivity, molecular pharmacology, psychiatric medication, antidepressants, antipsychotics, plasma concentration, therapeutic reference range
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:26 Nov 2010 15:36
Last Modified:13 Mar 2014 14:11
Item ID:17824
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