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Zusammenhang zwischen Quartärstruktur, Stabilität und katalytischer Aktivität am Beispiel der Anthranilat-Phosphoribosyltransferase

URN to cite this document: urn:nbn:de:bvb:355-epub-178806

Schwab, Thomas (2010) Zusammenhang zwischen Quartärstruktur, Stabilität und katalytischer Aktivität am Beispiel der Anthranilat-Phosphoribosyltransferase. PhD, Universität Regensburg

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Abstract (German)

In der vorliegenden Dissertation wurde der Zusammenhang zwischen der Quartärstruktur, der thermischen Stabilität und der enzymatischen Aktivität der Anthranilat-Phosphoribosyltransferase (AnPRT) untersucht, die in der Tryptophanbiosynthese den Mg2+-abhängigen Umsatz von Anthranilat (AA) und 5-Phosphoribosyl-α1-pyrophosphat (PRPP) zu Phosphoribosylanthranilat (PRA) und Pyrophosphat (PPi) ...

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Translation of the abstract (English)

The dissertation deals with the correlation of quaternary structure, thermal stability and enzymatic activity of the anthranilate phosphoribosyltransferase (AnPRT), which catalyzes the Mg2+-dependent turnover of anthranilate and 5-phosphoribosyl-α1-pyrophosphate (PRPP) to phosphoribosylanthranilate (PRA) and pyrophosphate (PPi). The first part of the work was based on the finding, that ...

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Item Type:Thesis of the University of Regensburg (PhD)
Date:26 November 2010
Referee:Prof. Dr. Reinhard Sterner
Date of exam:27 October 2010
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie
Research groups and research centres:Not selected
Keywords:Rationales Proteindesign, gelenkte Evolution, Thermostabilität, Anthranilat-Phosphoribosyltransferase
Subjects:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:26 Nov 2010 15:44
Last Modified:13 Mar 2014 14:12
Item ID:17880
Owner Only: item control page

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