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5-Acetoxy-2-(3-acetoxyphenyl)-3-ethyl-1-methyl-1H-indene: a new mammary tumor inhibiting compound

Schneider, Martin R. and von Angerer, Erwin and Schönenberger, Helmut (1982) 5-Acetoxy-2-(3-acetoxyphenyl)-3-ethyl-1-methyl-1H-indene: a new mammary tumor inhibiting compound. European journal of medicinal chemistry 17 (3), pp. 245-248.

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Abstract

The title indene I was prepd. by cyclization of hexanediol II. I has a marked affinity to the cytoplasmic estrogen receptor and only weak uterotrophic, but antiuterotrophic properties in the mouse uterine wt. bioassay. I inhibits the growth of the DMBA-induced, hormone-dependent mammary carcinoma of the ...

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Item Type:Article
Date:1982
Additional information (public):CAN 97:181898 25-23 Benzene, Its Derivatives, and Condensed Benzenoid Compounds 83456-27-3P; 83464-83-9P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and cyclocondensation of); 83456-28-4P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and demethylation-acetylation of); 83456-29-5P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn. and neoplasm inhibiting activity of); 37951-49-8 Role: RCT (Reactant), RACT (Reactant or reagent) (reductive dimerization of)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
1982:581898Other
Keywords:Neoplasm inhibitors (acetoxy(acetoxyphenyl)ethylmethylindene) Receptors Role: RCT (Reactant), RACT (Reactant or reagent) (for estrogens, (acetoxyphenyl)indene deriv. binding by, neoplasm inhibiting activity in relation to) acetoxyphenylindene ethylmethylacetoxy prepn tumor inhibitor indene acetoxyphenyl anticancer
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:18 Nov 2010 09:07
Last Modified:18 Nov 2010 09:07
Item ID:18106
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