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Studies of pharmacokinetics and metabolic behavior of N-L-phenylalanyl-L-2-amino-1-phenylpropane

Beck, D. and Hoelzl, J. and Schönenberger, Helmut (1981) Studies of pharmacokinetics and metabolic behavior of N-L-phenylalanyl-L-2-amino-1-phenylpropane. Arzneimittel-Forschung = Drug research 31 (10), pp. 1726-1731.

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Abstract

N-L-Phenylalanyl-L-2-amino-1-phenylpropane (I) was prepd. and its pharmacokinetics was studied in mice following i.p. administration. 14C accumulated in the gastrointestinal tract, liver, kidney, bile, and brain. The radioactivity was mainly excreted by the kidneys (54%) and in the feces (11%); at 48 h postadministration, the metab. of I was nearly complete (85%). In brain, the max. 14C-activity was obsd. at 0.25 h postadministration; 93.38% of the radioactivity was assocd. with I and its metabolite amphetamine (II) (quantity ratio of II:I = 1.43) and 5% with the hydroxylated metabolite of II. A continuous increase in spontaneous motility was obsd. in mice up to 4 h after I administration and this was attributed to II.

Item Type:

Article

Additional information (public):

CAN 96:62515 1-2 Pharmacology 300-62-9 Role: BIOL (Biological study) (as phenylalanylaminophenylpropane metabolite, pharmacokinetics in relation to); 61925-94-8 Role: BPR (Biological process), BSU (Biological study, unclassified), BIOL (Biological study), PROC (Process) (pharmacokinetics of); 5123-55-7P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and chlorination of); 80411-94-5P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and deprotection of); 32150-91-7P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction with methyleneaminophenylpropane); 80123-64-4P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 85-44-9 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with phenylalanine); 63-91-2 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with phthalic acid anhydride); 80411-93-4 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with phthalylphenylalanyl chloride)

Institutions:

Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger

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