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Studies of pharmacokinetics and metabolic behavior of N-L-phenylalanyl-L-2-amino-1-phenylpropane

Beck, D. and Hoelzl, J. and Schönenberger, Helmut (1981) Studies of pharmacokinetics and metabolic behavior of N-L-phenylalanyl-L-2-amino-1-phenylpropane. Arzneimittel-Forschung = Drug research 31 (10), pp. 1726-1731.

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Abstract

N-L-Phenylalanyl-L-2-amino-1-phenylpropane (I) was prepd. and its pharmacokinetics was studied in mice following i.p. administration. 14C accumulated in the gastrointestinal tract, liver, kidney, bile, and brain. The radioactivity was mainly excreted by the kidneys (54%) and in the feces (11%); at 48 h postadministration, the metab. of I was nearly complete (85%). In brain, the max. 14C-activity ...

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Item Type:Article
Date:1981
Additional information (public):CAN 96:62515 1-2 Pharmacology 300-62-9 Role: BIOL (Biological study) (as phenylalanylaminophenylpropane metabolite, pharmacokinetics in relation to); 61925-94-8 Role: BPR (Biological process), BSU (Biological study, unclassified), BIOL (Biological study), PROC (Process) (pharmacokinetics of); 5123-55-7P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and chlorination of); 80411-94-5P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and deprotection of); 32150-91-7P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction with methyleneaminophenylpropane); 80123-64-4P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 85-44-9 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with phenylalanine); 63-91-2 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with phthalic acid anhydride); 80411-93-4 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with phthalylphenylalanyl chloride)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Identification Number:
ValueType
1982:62515Other
Keywords:phenylalanylaminophenylpropane prepn pharmacokinetics aminophenylpropane deriv pharmacokinetics amphetamine
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Petra Gürster
Deposited On:22 Nov 2010 12:49
Last Modified:22 Nov 2010 12:49
Item ID:18112
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