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Synthesis, in vivo and in vitro studies on the antineoplastic effect of cis-dichloro-dipeptide ester-platinum(II) complexes

Beck, Wolfgang and Purucker, Bernhard and Girnth, Michael and Schönenberger, Helmut and Seidenberger, Horst and Ruckdeschel, Gotthard (1976) Synthesis, in vivo and in vitro studies on the antineoplastic effect of cis-dichloro-dipeptide ester-platinum(II) complexes. Zeitschrift für Naturforschung B: Anorganische Chemie, organische Chemie 31B (6), pp. 832-845.

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Cis-Cl2Pt(GlyGlyOEt)2 (I) [60426-60-0] (1.7 * 10-5M) inhibited DNA formation by sarcoma 180, Yoshida sarcoma, and Walker 256 carcinosarcoma in vitro. RNA and protein synthesis were inhibited to a lesser extent. I inhibited growth of Walker 256 carcinosarcoma by 78% at 380 mg/kg i.p. in rats and produced 30% cures; I was less effective against the other tumors in vivo. I caused filamentous growth ...


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Item type:Article
Additional Information (public):CAN 85:137309 1-5 Pharmacodynamics 15663-27-1 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (neoplasm inhibition by, dichlorodipeptide ester platinum complexes in relation to); 60426-60-0P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and neoplasm inhibitory activity of); 60399-15-7P; 60399-17-9P; 60399-19-1P; 60399-21-5P; 60399-23-7P; 60399-28-2P; 60399-29-3P; 60399-30-6P; 60554-12-3P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 60426-61-1 Role: BIOL (Biological study) (reaction with amino acid ethyl esters); 459-73-4 Role: BIOL (Biological study) (reaction with amino acid platinum complexes); 10025-99-7 Role: BIOL (Biological study) (reaction with dipeptide ethyl esters); 15654-65-6; 15654-80-5; 21434-59-3 Role: BIOL (Biological study) (reaction with glycine ethyl ester); 26348-61-8 Role: BIOL (Biological study) (reaction with glycine nitrophenol ester platinum complex); 100-02-7 Role: BIOL (Biological study) (reaction with glycine platinum complex); 17567-45-2 Role: BIOL (Biological study) (reaction with nitrophenol); 2087-41-4; 60392-15-6 Role: BIOL (Biological study) (reaction with potassium chloroplatinate)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Identification Number:
Keywords:Bactericides, Disinfectants and Antiseptics Neoplasm inhibitors (dichlorodipeptide ester platinum complexes) Deoxyribonucleic acids Proteins Ribonucleic acids Role: FORM (Formation, nonpreparative) (formation of, by neoplasm, dichlorodipeptide ester platinum complex inhibition of) peptide platinum complex neoplasm inhibitor
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Deposited on:22 Nov 2010 12:48
Last modified:22 Nov 2010 12:48
Item ID:18113
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