Dhople, A. M. and Strong, L. C. and Meindl, W. and Schönenberger, Helmut and Gardner, G. D. (1991) In vitro and in vivo effects of N-methyl-3,5-dichlorobenzylamine hydrochloride on Mycobacterium leprae. Arzneimittel-Forschung = Drug research 41 (3), pp. 253-256.
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The antimicrobial effects of a new benzylamine, ME-93 (I), alone and in combination with dapsone and rifampicin, have been evaluated in vitro in cell-free culture system and in vivo in mouse foot pad system. Even at 50 micro g/mL, ME-93 did not completely inhibit the in vitro growth of M. leprae, and the effects were bacteriostatic. However, there was a synergism when ME-93 was combined with rifampicin, and the effects were bactericidal. Similar findings were also obtained in the mouse foot pad system. Thus, there is a new drug that needs further attention in the chemotherapy of leprosy.
|Additional information (public):||CAN 115:270 1-5 Pharmacology 80-08-0 (Dapsone); 13292-46-1 (Rifampicin) Role: BIOL (Biological study) (Mycobacterium leprae inhibition by benzylamine enhancement by); 90389-22-3 (ME 93) Role: BIOL (Biological study) (Mycobacterium leprae inhibition by, dapsone and rifampicin enhancement of)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Mycobacterium leprae (inhibition of, by benzylamine, dapsone and rifampicin enhancement of) benzylamine Mycobacterium inhibition dapsone rifampicin leprosy treatment benzylamine ME93 Mycobacterium inhibition|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||22 Nov 2010 12:41|
|Last Modified:||22 Nov 2010 12:41|