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In vitro and in vivo effects of N-methyl-3,5-dichlorobenzylamine hydrochloride on Mycobacterium leprae

Dhople, A. M. and Strong, L. C. and Meindl, W. and Schönenberger, Helmut and Gardner, G. D. (1991) In vitro and in vivo effects of N-methyl-3,5-dichlorobenzylamine hydrochloride on Mycobacterium leprae. Arzneimittel-Forschung = Drug research 41 (3), pp. 253-256.

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Abstract

The antimicrobial effects of a new benzylamine, ME-93 (I), alone and in combination with dapsone and rifampicin, have been evaluated in vitro in cell-free culture system and in vivo in mouse foot pad system. Even at 50 micro g/mL, ME-93 did not completely inhibit the in vitro growth of M. leprae, and the effects were bacteriostatic. However, there was a synergism when ME-93 was combined with ...

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Item Type:Article
Date:1991
Additional information (public):CAN 115:270 1-5 Pharmacology 80-08-0 (Dapsone); 13292-46-1 (Rifampicin) Role: BIOL (Biological study) (Mycobacterium leprae inhibition by benzylamine enhancement by); 90389-22-3 (ME 93) Role: BIOL (Biological study) (Mycobacterium leprae inhibition by, dapsone and rifampicin enhancement of)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Identification Number:
ValueType
1991:400270Other
Keywords:Mycobacterium leprae (inhibition of, by benzylamine, dapsone and rifampicin enhancement of) benzylamine Mycobacterium inhibition dapsone rifampicin leprosy treatment benzylamine ME93 Mycobacterium inhibition
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Petra Gürster
Deposited On:22 Nov 2010 12:41
Last Modified:22 Nov 2010 12:41
Item ID:18116
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