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Synthesis of spasmolytic N-[(diphenylacetamido)methyl]dimethylalkyammonium iodides

Petter, A. and Schönenberger, Helmut and Gutschow, K. and Kuehling, V. and Taneja, V. (1972) Synthesis of spasmolytic N-[(diphenylacetamido)methyl]dimethylalkyammonium iodides. Archiv der Pharmazie 305 (11), pp. 820-828.

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Abstract

Ten Ph2CHCONHCH2N+Me2(CH2)nMe I- (I, n = 0-9) were prepd. by reaction of Ph2CHCONH2, paraformaldehyde, and HNMe(CH2)nMe and subsequent quaternization. I (n = 0-2) and I (n = 3-9) had competitive and noncompetitive, resp., antagonistic effects against acetylcholine on the isolated rat jejunum. Increased chain length led to increased spasmolytic activity of the latter. I (n = 9) was 20 times more ...

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Item Type:Article
Date:1972
Additional information (public):CAN 78:57971 25-19 Noncondensed Aromatic Compounds 39075-51-9P; 39075-52-0P; 39075-53-1P; 39075-54-2P; 39075-55-3P; 39075-56-4P; 39075-57-5P; 39131-60-7P; 39242-43-8P; 39479-59-9P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and spasmolytic activity of); 39075-50-8P; 39093-28-2P; 39093-29-3P; 39093-30-6P; 39093-31-7P; 39093-32-8P; 39093-33-9P; 39093-34-0P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 74-88-4; 75-03-6; 107-08-4; 542-69-8; 628-17-1; 629-27-6; 638-45-9; 2050-77-3; 4282-40-0; 4282-42-2 Role: RCT (Reactant), RACT (Reactant or reagent) (quaternization by, of [(methylamino)methyl]diphenylacetamides); 109-73-9; 2439-54-5; 7516-82-7; 25419-06-1; 35161-70-7; 36343-05-2; 39093-27-1 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with paraformaldehyde and diphenylacetamide); 4695-13-0 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with paraformaldehyde and methylalkylamines); 124-40-3 Role: RCT (Reactant), RACT (Reactant or reagent) (with paraformaldehyde and diphenylacetamide)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Identification Number:
ValueType
1973:57971Other
Keywords:Muscle relaxants (alkyl[(diphenylacetamido)methyl]dimethylammonium iodides) phenylacetamidomethylammonium iodide spasmolytic acetamidomethylammonium ammonium diphenylacetamidomethyl iodide acetamidomethylammonium iodide
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Petra Gürster
Deposited On:22 Nov 2010 12:23
Last Modified:22 Nov 2010 12:23
Item ID:18123
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