Petter, A. and Schönenberger, Helmut and Zwez, W. (1972) Mode of action of local anesthetics. 4. Correlation between lipid solubility and biological activity of diastereomeric N-[N-dimethylphenylalanyl]ephedrine. Detection of asymmetric membrane structures as the site of action of local anesthetics. Pharmazie 27 (8), pp. 524-525.
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No correlation existed between the lipid soly., basicity, or water soly. of diastereomeric N-(N,N-dimethylphenylalanyl)ephedrine (I) [37102-67-3] and its local anesthetic action. The stereoisomer, N-(L-N,N-dimethylphenylalanyl)-L-pseudoephedrine [14645-40-0] showed the highest lipid soly. but the least anesthetic action. This lack of correlation between lipid soly. and anesthetic action indicated that the site for anesthetic effects on the membrane was probably protein in nature.
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|Additional Information (public):||CAN 78:104 1-4 Pharmacodynamics 14536-74-4; 14536-75-5; 39953-32-7; 39953-33-8; 39953-34-9; 39953-36-1 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (anesthetic activity of, lipid soly. in relation to)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Lipids Role: BIOL (Biological study) (anesthetic diastereomers of (dimethylphenylalanyl)ephedrine and (dimethylphenylalanyl)pseudoephedrine soly. in) Molecular structure-biological activity relationship (anesthetic, of (dimethylphenylalanyl)ephedrine and (dimethylphenylalanyl)pseudoephedrine diastereomers) Anesthesia (from (dimethylphenylalanyl)ephedrine and (dimethylphenylalanyl)pseudoephedrine diastereomers, lipid soly. in relation) ephedrine diastereoisomer anesthetic lipid soly ephedrine anesthetic|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||22 Nov 2010 12:18|
|Last Modified:||22 Nov 2010 12:18|