Petter, A. and Schönenberger, Helmut and Zwez, W. (1972) Mode of action of local anesthetics. 4. Correlation between lipid solubility and biological activity of diastereomeric N-[N-dimethylphenylalanyl]ephedrine. Detection of asymmetric membrane structures as the site of action of local anesthetics. Pharmazie 27 (8), pp. 524-525.
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No correlation existed between the lipid soly., basicity, or water soly. of diastereomeric N-(N,N-dimethylphenylalanyl)ephedrine (I) [37102-67-3] and its local anesthetic action. The stereoisomer, N-(L-N,N-dimethylphenylalanyl)-L-pseudoephedrine [14645-40-0] showed the highest lipid soly. but the least anesthetic action. This lack of correlation between lipid soly. and anesthetic action indicated ...
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|Additional information (public):||CAN 78:104 1-4 Pharmacodynamics 14536-74-4; 14536-75-5; 39953-32-7; 39953-33-8; 39953-34-9; 39953-36-1 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (anesthetic activity of, lipid soly. in relation to)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Lipids Role: BIOL (Biological study) (anesthetic diastereomers of (dimethylphenylalanyl)ephedrine and (dimethylphenylalanyl)pseudoephedrine soly. in) Molecular structure-biological activity relationship (anesthetic, of (dimethylphenylalanyl)ephedrine and (dimethylphenylalanyl)pseudoephedrine diastereomers) Anesthesia (from (dimethylphenylalanyl)ephedrine and (dimethylphenylalanyl)pseudoephedrine diastereomers, lipid soly. in relation) ephedrine diastereoisomer anesthetic lipid soly ephedrine anesthetic|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||22 Nov 2010 12:18|
|Last Modified:||22 Nov 2010 12:18|