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Mode of action of local anesthetics. 4. Correlation between lipid solubility and biological activity of diastereomeric N-[N-dimethylphenylalanyl]ephedrine. Detection of asymmetric membrane structures as the site of action of local anesthetics

Petter, A. and Schönenberger, Helmut and Zwez, W. (1972) Mode of action of local anesthetics. 4. Correlation between lipid solubility and biological activity of diastereomeric N-[N-dimethylphenylalanyl]ephedrine. Detection of asymmetric membrane structures as the site of action of local anesthetics. Pharmazie 27 (8), pp. 524-525.

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Abstract

No correlation existed between the lipid soly., basicity, or water soly. of diastereomeric N-(N,N-dimethylphenylalanyl)ephedrine (I) [37102-67-3] and its local anesthetic action. The stereoisomer, N-(L-N,N-dimethylphenylalanyl)-L-pseudoephedrine [14645-40-0] showed the highest lipid soly. but the least anesthetic action. This lack of correlation between lipid soly. and anesthetic action indicated ...

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Item Type:Article
Date:1972
Additional information (public):CAN 78:104 1-4 Pharmacodynamics 14536-74-4; 14536-75-5; 39953-32-7; 39953-33-8; 39953-34-9; 39953-36-1 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (anesthetic activity of, lipid soly. in relation to)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Identification Number:
ValueType
1973:104Other
Keywords:Lipids Role: BIOL (Biological study) (anesthetic diastereomers of (dimethylphenylalanyl)ephedrine and (dimethylphenylalanyl)pseudoephedrine soly. in) Molecular structure-biological activity relationship (anesthetic, of (dimethylphenylalanyl)ephedrine and (dimethylphenylalanyl)pseudoephedrine diastereomers) Anesthesia (from (dimethylphenylalanyl)ephedrine and (dimethylphenylalanyl)pseudoephedrine diastereomers, lipid soly. in relation) ephedrine diastereoisomer anesthetic lipid soly ephedrine anesthetic
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Petra Gürster
Deposited On:22 Nov 2010 12:18
Last Modified:22 Nov 2010 12:18
Item ID:18126
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