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Mechanism of action of local anesthetics. 2. Demonstration of the differential effect of enantiomeric local anesthetics

Petter, A. and Schönenberger, Helmut and Zwez, W. (1972) Mechanism of action of local anesthetics. 2. Demonstration of the differential effect of enantiomeric local anesthetics. Pharmazie 27 (4), pp. 250-255.

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Abstract

The 8 stereoisomers of N-[N-dimethylphenylalanyl]ephedrine [10385-91-8], the 2 stereoisomers of N-[N-dimethylalanyl]-2,6-dimethylaniline [19216-39-8] (I, R = H), and the 2 stereoisomers of N-[N-dimethylphenylalanyl]-2,6-dimethylaniline [19216-40-1] (I, R = Ph) were synthesized and tested, as models of local anesthetics, for their ability to slow the impulse conduction velocity of frog ventricle ...

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Item Type:Article
Date:1972
Additional information (public):CAN 77:43086 1-3 Pharmacodynamics 2480-20-8; 2673-32-7; 5042-94-4; 7232-10-2; 7232-11-3; 7232-12-4; 7275-84-5; 7278-68-4; 19216-71-8; 19216-72-9; 19216-73-0; 19237-86-6 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (local anesthetic activity of)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Identification Number:
ValueType
1972:443086Other
Keywords:Anesthetics (local, dimethylaniline and ephedrine enantiomers as) local anesthetic membrane protein nerve conduction anesthetic
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Petra Gürster
Deposited On:22 Nov 2010 12:16
Last Modified:22 Nov 2010 12:16
Item ID:18127
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