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The carcinostatic effects of amino alkylating compounds. I. Cytostatic compounds

Schönenberger, Helmut and Adam, A. (1964) The carcinostatic effects of amino alkylating compounds. I. Cytostatic compounds. Arzneimittel-Forschung = Drug research 14 (10), p. 1168.

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Abstract

The cystostatic effects were established of 5 new classes of compds., e.g. (Me2N)2CH2, (EtSCH2NMeCH2)2, Me2NCH2S2CNMe2, N,N'-bis(ethylthiomethyl)imidazolidine, and 1,4,6,9-tetraazatricyclo[4.4.1.1.4.9]dodecane. The tests were carried out on the Ehrlich ascites tumor in mice. The compds. probably act via alpha -amino alkylation of biol. important substrates. With the compds. 70-90% of the animals survived for >=60 days while the controls had a mean life of 15 days.

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Article

Additional information (public):

CAN 62:39497 68 Pharmacodynamics 5751-48-4 (Derived from data in the 7th Collective Formula Index (1962-1966); 51-46-7 (1,3,6,8-Tetraazatricyclo[4.4.1.13,8]dodecane); 51-69-4 (Imidazolidine, 1,3-bis[(ethylthio)methyl]-); 51-76-3 (Ethylenediamine, N,N'-bis[(ethylthio)methyl]-N,N'-dimethyl-); 51-80-9 (Methanediamine, N,N,N',N'-tetramethyl-); 51-82-1 (Methanethiol, (dimethylamino)-, dimethyldithiocarbamate) (carcinoma inhibition by)

Institutions:

Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger

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