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Chemistry and mode of action of aminomethylating carcinostatics. II. Cytostatics

Schönenberger, Helmut and Adam, Adelheid (1965) Chemistry and mode of action of aminomethylating carcinostatics. II. Cytostatics. Arzneimittel-Forschung = Drug research 15 (1), pp. 30-36.

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Abstract

cf. CA 63, 5474c. The growth of Ehrlich ascites tumor in mice was inhibited by mono- and dialkylthiomethylamine derivs., which react with the higher H+ concn. in tumor cells to give carbonium-immoninm ions which alkylate the substrate. The low toxicity of these compds. is explained by the ease with which the alpha -aminoalkyl radical splits from the blocked substrate. Melamine and formalin at pH ...

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Item Type:Article
Date:1965
Additional information (public):CAN 64:93484 38 Heterocyclic Compounds (More Than One Hetero Atom) 203209-59-0P; 1081773-77-4P; 1081773-86-5P Role: SPN (Synthetic preparation), PRP (Properties), PREP (Preparation) (Chemistry and mode of action of aminomethylating carcinostatics. II. Cytostatics); 51-46-7P (1,3,6,8-Tetraazatricyclo[4.4.1.13,8]dodecane); 51-69-4P (Imidazolidine, 1,3-bis[(ethylthio)methyl]-); 51-76-3P (Ethylenediamine, N,N'-bis[(ethylthio)methyl]-N,N'-dimethyl-); 51-76-3P (3,10-Dithia-5,8-diazadodecane, 5,8-dimethyl-); 51-80-9P (Methanediamine, N,N,N',N'-tetramethyl-); 51-82-1P (Carbamic acid, dimethyldithio-, (dimethylamino)methyl ester); 110-81-6P (Ethyl disulfide); 1017-56-7P (Methanol, (s-triazine-2,4,6-triyltriimino)tri-); 1952-37-0P (Ethanol, 2-[(p-hydroxybenzylidene)amino]-); 2037-00-5P (Methanol, (diethylamino)-, acetate (ester); 3089-11-0P (Melamine, hexakis(methoxymethyl)-); 3275-13-6P (Piperidine, 1-(ethoxymethyl)-); 4135-86-8P (Ethylenediamine, N,N'-bis[(ethylthio)methyl]-N,N'-dimethyl-, dihydrochloride); 4396-19-4P (Methane, bis(ethylthio)-); 5752-37-4P (Melamine, hexakis[(ethylthio)methyl]-); 5752-40-9P (Ethylenediamine, N,N'-dimethyl-, dihydrochloride); 5752-42-1P (Imidazolidine, 1,3-bis[(ethylthio)methyl]-, hydrochloride); 5752-43-2P (Ethylenediamine, N,N,N',N'-tetrakis[(ethylthio)methyl]-); 5766-67-6P (Acetonitrile, (ethylenedinitrilo)tetra-); 5766-68-7P (Glycinonitrile, N,N'-ethylenebis[N-methyl-); 5766-69-8P (Glycinonitrile, N,N'-(6-chloro-s-triazine-2,4-diyl)di-); 5766-70-1P (Acetonitrile, [(6-amino-s-triazine-2,4-diyl)diimino]di-); 5766-71-2P (Glycinonitrile, N,N',N''-s-triazine-2,4,6-triyltri-); 5766-74-5P (Phenol, p-(N-methylformimidoyl)-); 5766-75-6P (Pyrocatechol, 4-(N-methylformimidoyl)-); 5766-76-7P (Anthranilic acid, N-benzylidene-); 5766-79-0P (1-Piperidineacetonitrile, alpha -phenyl-); 860394-79-2P (3,10-Dithia-5,8-diazadodecane, 5,8-dimethyl-, dihydrochloride) Role: PREP (Preparation) (prepn. of)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Identification Number:
ValueType
1966:93484Other
Keywords:Aminomethylation (by cancer-inhibiting substances) Cancer (inhibitors of, aminomethylating substances as)
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Petra Gürster
Deposited On:19 Nov 2010 09:55
Last Modified:19 Nov 2010 09:55
Item ID:18135
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