Schönenberger, Helmut and Adam, Dieter (1966) The cytostatic effect of isomeric diethylstilbestrols. IV. Antimycotics. Arzneimittel-Forschung = Drug research 16 (6), pp. 738-740.
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Diethylstilbestrol (4,4'-dihydroxy-alpha -beta -diethyl-stilbene) has substantial fungistatic and bacteriostatic properties in addn. to its estrogenic activity. However, by shifting the phenolic OH groups to the meta position as in 3,3'-dihydroxy-alpha beta -diethylstilbene, the hormonal effect is largely lost, while the antimycotic and antibacterial properties are fully retained. Owing to its negligible hormonal side effects, 3,3'-dihydroxy-alpha ,beta -diethylstilbene thus is highly suitable for antimycotic therapy. 2,2'-Dihydroxy-alpha ,beta -diethylstilbene had neither hormonal nor antimycotic and antibacterial activity. 50 references.
|Additional information (public):||CAN 65:76270 68 Pharmacodynamics 10590-39-3 (Derived from data in the 7th Collective Formula Index (1962-1966); 6898-97-1 (4,4'-Stilbenediol, alpha ,alpha '-diethyl-) (bactericidal and fungicidal activity of, structure and); 604-52-4 (2,2'-Stilbenediol, alpha ,alpha '-diethyl-) (bactericidal, estrogenic and fungicidal activity in relation to); 80149-87-7P (3,3'-Stilbenediol, alpha ,alpha '-diethyl-) Role: PREP (Preparation) (prepn. of)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Fungicides or Fungistats (diethylstilbestrol) Bactericidal action or Bacteriostatic action (of alpha ,alpha '-diethylstilbenediols)|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||19 Nov 2010 09:53|
|Last Modified:||19 Nov 2010 09:53|