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Cytostatics. 17. The antimicrobial and antitumor activity of Mannich bases of 3,3'- and 4,4'-dihydroxy-alpha ,beta -diethylstilbene

Schönenberger, Helmut and Adam, D. and Alonso, G. and Adam, A. (1972) Cytostatics. 17. The antimicrobial and antitumor activity of Mannich bases of 3,3'- and 4,4'-dihydroxy-alpha ,beta -diethylstilbene. Archiv der Pharmazie 305 (4), pp. 300-308.

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Abstract

Four 4,3-R(R1)C6H3CEt:CEtC6H3(R2)R-3,4 (I, R = OH or CH2NMe2; R1 = H or R2; R2 = OH, CH2NMe2, CH2NMeCH2CH2NMe2), prepd. by reaction of the title dihydroxy-alpha ,beta -diethylstilbenes with Me2NCH2Cl or Me2NCH2CH2NMeCH2Cl, resp., had little in vitro antimicrobial effect and caused little inhibition of rat Yoshida sarcoma in vivo. Only 2 I (R = OH, R1 = H, R2 = CH2NMe2; R = OH, R1 = R2 = CH2NMe2) ...

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Item Type:Article
Date:1972
Additional information (public):CAN 77:56510 1-5 Pharmacodynamics 24524-66-1; 37013-41-5 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (neoplasm inhibitory activity of); 12786-24-2P; 37013-42-6P; 37013-44-8P; 37013-45-9P; 37013-47-1P; 37013-48-2P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 5959-71-7 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with (chloromethyl) dimethylamine); 56-53-1 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with (chloromethyl)dimethylamine and (chloromethyl) trimethylethylenediamine); 30438-74-5; 37013-40-4 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with dihydroxydiethylstilbene); 142-25-6 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with formaldehyde)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Identification Number:
ValueType
1972:456510Other
Keywords:Bactericides, Disinfectants and Antiseptics Neoplasm inhibitors (Mannich bases of dihydroxydiethylstilbenes) Mannich bases Role: BIOL (Biological study) (of dihydroxydiethylstilbenes) Mannich base stilbene antimicrobial antitumor antitumor Mannich base stilbene cytostatic Mannich base stilbene aminomethylstilbene cytostatic
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Petra Gürster
Deposited On:19 Nov 2010 09:50
Last Modified:19 Nov 2010 09:51
Item ID:18138
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