Deutsch
Schönenberger, Helmut and Bastug, T. (1971) Cytostatic drugs. 10. Relations between stability and antimicrobial activity of beta-aminoketones. Arzneimittel-Forschung = Drug research 21 (1), pp. 68-75.
Full text not available from this repository.
Abstract
The antimicrobial activity of 6 beta -aminopropio-phenones (I), 4 alpha -phenyl-beta -aminopropiophenones (II), and 2 alpha -phenyl-beta -aminoketones (III) increased with increasing in-stability in aq. solns. at pH 7.35 and 37 Deg. Compds. which did not decomp. under these physiol. conditions also showed no biol. activity. The effect of I and III was due to release of an alpha ,beta -unsatd. ketone, whereas II formed CH2O and alpha ,beta -unsatd. ketones under physiol. conditions.
| Item Type: | Article | ||||
|---|---|---|---|---|---|
| Additional information (public): | CAN 74:84349 8 Microbial Biochemistry 91-03-2; 94-38-2; 94-39-3; 1892-36-0; 2138-33-2; 2138-38-7; 3506-36-3; 22563-99-1; 25527-39-3; 25527-41-7; 27702-63-2; 27702-65-4 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (antimicrobial activity of, stability in relation to) | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger | ||||
| Identification Number: |
| ||||
| Keywords: | Mannich bases Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (antimicrobial activity of) Molecular structure-biological activity relationships (antimicrobial, of aminoketones) Bactericidal action (of aminoketones) aminoketones stability antimicrobial activity antimicrobial activity aminoketones stability ketone antimicrobial activity aminopropiophenones antimicrobial activity | ||||
| Subjects: | 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Unknown | ||||
| Owner: | Petra Gürster | ||||
| Deposited On: | 19 Nov 2010 10:47 | ||||
| Last Modified: | 19 Nov 2010 10:47 | ||||
| Item ID: | 18141 |
Export bibliographical data
Literature of the same author
in this repositoryat BASEat Google Scholarat Scirus
Bookmark
- ASCII Citation
- BibTeX
- Dublin Core
- EndNote
- HTML Citation
- METS
- OAI-ORE Resource Map (Atom Format)
- OAI-ORE Resource Map (RDF Format)
- RDF+N-Triples
- RDF+N3
- RDF+XML
- Refer
- Reference Manager
- Simple Metadata
- XML
- xMetaDissPlus
Literature of the same author
in this repositoryat BASEat Google Scholarat ScirusBookmark
Citeulike
Connotea
Del.icio.us
Digg
Facebook
Owner Only: item control page