Schönenberger, Helmut and Bastug, T. (1971) Cytostatic drugs. 10. Relations between stability and antimicrobial activity of beta-aminoketones. Arzneimittel-Forschung = Drug research 21 (1), pp. 68-75.
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The antimicrobial activity of 6 beta -aminopropio-phenones (I), 4 alpha -phenyl-beta -aminopropiophenones (II), and 2 alpha -phenyl-beta -aminoketones (III) increased with increasing in-stability in aq. solns. at pH 7.35 and 37 Deg. Compds. which did not decomp. under these physiol. conditions also showed no biol. activity. The effect of I and III was due to release of an alpha ,beta -unsatd. ...
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|Additional information (public):||CAN 74:84349 8 Microbial Biochemistry 91-03-2; 94-38-2; 94-39-3; 1892-36-0; 2138-33-2; 2138-38-7; 3506-36-3; 22563-99-1; 25527-39-3; 25527-41-7; 27702-63-2; 27702-65-4 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (antimicrobial activity of, stability in relation to)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Mannich bases Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (antimicrobial activity of) Molecular structure-biological activity relationships (antimicrobial, of aminoketones) Bactericidal action (of aminoketones) aminoketones stability antimicrobial activity antimicrobial activity aminoketones stability ketone antimicrobial activity aminopropiophenones antimicrobial activity|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||19 Nov 2010 09:47|
|Last Modified:||19 Nov 2010 09:47|