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Cytostatics. 15. Antimicrobial and antitumor properties of nitrogen-containing stilbestrol analogs

Schönenberger, Helmut and Bastug, T. (1972) Cytostatics. 15. Antimicrobial and antitumor properties of nitrogen-containing stilbestrol analogs. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 305 (4), pp. 285-290.

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Abstract

Me2NCH2C(C6H4R-p):C(C6H4R-p)Et [I, R = H (II) or OMe (III)] were prepd. by reaction of Me2NCH2CH(C6H4R-p)COC6H4R-p with EtMgBr and dehydration of the resulting alc. with PCl3. Ether cleavage of III with AlBr3 in C6H6 gave I [R = OH (IV)]. II and IV had no estrogenic properties. II, III, and IV showed no antibacterial effects in vitro and only low activity against mouse sarcoma 180 and rat Yoshida sarcoma in vivo. II caused good inhibition of rat mammary carcinoma. The i.p. LD50 values of II, III, and IV were 120, 160, and 150 mg/kg, resp., in rats.

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Article

Additional information (public):

CAN 77:56509 1-5 Pharmacodynamics 1081531-11-4P; 1086262-18-1P; 1086262-35-2P Role: SPN (Synthetic preparation), PRP (Properties), PREP (Preparation) (Cytostatics. 15. Antimicrobial and antitumor properties of nitrogen-containing stilbestrol analogs); 1892-36-0; 22563-99-1 Role: RCT (Reactant), RACT (Reactant or reagent) (Grignard reaction of); 37013-31-3 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (neoplasm inhibitor activity of); 37013-30-2P; 37013-32-4P; 37013-33-5P; 37013-34-6P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of)

Institutions:

Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger

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