Schönenberger, Helmut and Bastug, T. (1972) Cytostatics. 15. Antimicrobial and antitumor properties of nitrogen-containing stilbestrol analogs. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 305 (4), pp. 285-290.
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Me2NCH2C(C6H4R-p):C(C6H4R-p)Et [I, R = H (II) or OMe (III)] were prepd. by reaction of Me2NCH2CH(C6H4R-p)COC6H4R-p with EtMgBr and dehydration of the resulting alc. with PCl3. Ether cleavage of III with AlBr3 in C6H6 gave I [R = OH (IV)]. II and IV had no estrogenic properties. II, III, and IV showed no antibacterial effects in vitro and only low activity against mouse sarcoma 180 and rat Yoshida ...
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|Additional Information (public):||CAN 77:56509 1-5 Pharmacodynamics 1081531-11-4P; 1086262-18-1P; 1086262-35-2P Role: SPN (Synthetic preparation), PRP (Properties), PREP (Preparation) (Cytostatics. 15. Antimicrobial and antitumor properties of nitrogen-containing stilbestrol analogs); 1892-36-0; 22563-99-1 Role: RCT (Reactant), RACT (Reactant or reagent) (Grignard reaction of); 37013-31-3 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (neoplasm inhibitor activity of); 37013-30-2P; 37013-32-4P; 37013-33-5P; 37013-34-6P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger|
|Keywords:||Neoplasm inhibitors (stilbestrol analogs as) stilbestrol deriv antitumor aminostilbestrol cancer inhibition carcinoma mammary aminostilbene|
|Dewey Decimal Classification:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited on:||19 Nov 2010 09:45|
|Last modified:||19 Nov 2010 09:45|