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Cytostatics. 21. Synthesis and carcinostatic action of N-[bis(2-chloroethyl)aminomethyl]amides

Schönenberger, Helmut and Bindl, L. and Adam, A. (1973) Cytostatics. 21. Synthesis and carcinostatic action of N-[bis(2-chloroethyl)aminomethyl]amides. Archiv der Pharmazie 306 (1), pp. 64-75.

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Abstract

Ten title compds. RCONHCH2N(CH2CH2Cl)2 (I, R = Ph, 4-ClC6H4, 3-ClC6H4, 2-ClC6H4, 4-BrC6H4, 4-FC6H4, 4-O2NC6H4, 3-O2NC6H4, 4-MeC6H4, and CCl3 were prepd. by reaction of RCONHCH2Cl and NH(CH2CH2Cl)2 in Et2O at 0 Deg. All I had a higher carcinostatic activity on Yoshida sarcoma of rats and sarcoma 180 of mice than bis(2-chloroethyl)amine and were at least as effective as ...

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Item Type:Article
Date:1973
Additional information (public):CAN 78:97223 25-4 Noncondensed Aromatic Compounds 55-21-0; 609-66-5; 618-48-4; 619-55-6; 619-56-7; 619-80-7; 645-09-0; 698-67-9; 824-75-9 Role: RCT (Reactant), RACT (Reactant or reagent) (hydroxymethylation of); 6282-02-6P; 13855-74-8P; 25223-87-4P; 27855-43-2P; 31220-71-0P; 40478-06-6P; 40478-07-7P; 40478-09-9P; 40478-10-2P; 40478-11-3P; 40478-12-4P; 40478-14-6P; 40478-15-7P; 40478-16-8P; 40478-17-9P; 40478-18-0P; 40478-19-1P; 40478-20-4P; 40478-21-5P; 40478-22-6P; 40478-23-7P; 40478-24-8P; 40478-25-9P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Identification Number:
ValueType
1973:97223Other
Keywords:Amides Role: RCT (Reactant), RACT (Reactant or reagent) (Mannich reaction with bis(chloroethyl)amine, attempted) Neoplasm inhibitors (bis(2-chloroethyl)aminomethyl amides) benzamide bischloroethylaminomethyl carcinostatic chloroethylaminomethylbenzamide carcinostatic sarcoma chloroethylaminomethylbenzamide acetamide trichloro carcinostatic
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Petra Gürster
Deposited On:19 Nov 2010 09:39
Last Modified:19 Nov 2010 09:39
Item ID:18146
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