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Cytostatics. 21. Synthesis and carcinostatic action of N-[bis(2-chloroethyl)aminomethyl]amides

Schönenberger, Helmut ; Bindl, L. ; Adam, A.



Zusammenfassung

Ten title compds. RCONHCH2N(CH2CH2Cl)2 (I, R = Ph, 4-ClC6H4, 3-ClC6H4, 2-ClC6H4, 4-BrC6H4, 4-FC6H4, 4-O2NC6H4, 3-O2NC6H4, 4-MeC6H4, and CCl3 were prepd. by reaction of RCONHCH2Cl and NH(CH2CH2Cl)2 in Et2O at 0 Deg. All I had a higher carcinostatic activity on Yoshida sarcoma of rats and sarcoma 180 of mice than bis(2-chloroethyl)amine and were at least as effective as bis(2-chloroethyl)methylamine.


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