Schönenberger, Helmut and Endres, W. (1976) Research on the mechanism of action of local anesthetics. Part 7: Synthesis of N-aminoacyl-2,6-dimethylaniline, - benzylamine and -2-phenylethylamine enantiomers. Pharmazie 31 (1), pp. 30-32.
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N-Phthaloyl amino acids were converted by PCl5 into their acid chlorides, which were used to acylate RNH2 (I, R = 2,6-Me2C6H3, PhCH2, and PhCH2CH2) and the amides were hydrazinolyzed to remove the protective group and give D- and L-H2NCHR1CONHR (R as in I, R1 = Me, Me2CH, Me2CHCH2, PhCH2).
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|Additional information (public):||CAN 92:41517 25-19 Noncondensed Aromatic Compounds 3183-10-6; 4306-25-6; 5511-73-9; 53100-40-6; 72212-78-3 Role: RCT (Reactant), RACT (Reactant or reagent) (acylation with, of xylidine); 32150-91-7; 32150-92-8 Role: RCT (Reactant), RACT (Reactant or reagent) (acylation with, of xylidine, benzylamine and phenylethylamine); 64991-26-0P; 72212-71-6P; 72213-20-8P; 72213-21-9P; 72213-22-0P; 72213-23-1P; 72213-24-2P; 72213-25-3P; 72213-26-4P; 72213-27-5P; 72215-90-8P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and hydrazinolysis of); 6455-20-5P; 35402-94-9P; 53984-74-0P; 53984-76-2P; 72212-72-7P; 72212-73-8P; 72212-74-9P; 72212-75-0P; 72212-76-1P; 72212-77-2P; 72244-52-1P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 64-04-0; 87-62-7; 100-46-9 Role: RCT (Reactant), RACT (Reactant or reagent) (N-(aminoacylation) of)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Amino acids Role: SPN (Synthetic preparation), PREP (Preparation) (arom. amide derivs., prepn. of) amino acid amide xylyl phenylalkyl aniline dimethyl aminoacyl benzylamine aminoacyl phenethylamine aminoacyl|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||19 Nov 2010 09:23|
|Last Modified:||19 Nov 2010 09:23|