Schönenberger, Helmut and Fuchsberger, K. D. and Petter, Alfred and Brinkmann, Rolf (1967) Interrelations between drug and receptor for N-aminoacylephedrine local anesthetics. Pharmaceutica acta Helvetiae 42 (3), pp. 163-176.
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The ability of N-(L-N-dimethylphenylalanyl)-D-ephedrine, N-(D-N-dimethylphenylalanyl)-L-ephedrine, N-(L-N-dimethylphenyl-alanyl)-L-ephedrine, N-(D-N-dimethylphenylalanyl)-D-ephedrine, N(L-N-dimethylphenylalanyl)-D-y-ephedrine, N-(D-N-dimethylphenylalanyl)-L-y-ephedrine, N-(L-N-dimethylphenylalanyl)-L-y-ephedrine, and N-(D-N-dimethylphenylalanyl)-D-y-ephedrine to block the isolated ischiadic nerve of the frog (Rana esculenta) was studied. Derivs. contg. L-phenylalanine showed the strongest anesthetic activity. Hypothetical representation of the drug-receptor binding of the anantiomers as well as a hypothetical receptor were proposed. 28 references.
|Additional information (public):||CAN 66:63963 15 Pharmacodynamics 7232-10-2 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (anesthetic activity of, nerve receptor and)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Anesthetics (N-aminoacylephedrine derivs. as local) Nerves (blocking agents for, N-aminoacylephedrine derivs. as, chemoreceptors and) Hydrocinnamamide Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (anesthetic activity of, nerve receptor and) EPHEDRINES PHENYLALANINE PHENYLALANINE EPHEDRINES ANESTHETICS EPHEDRINES|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||19 Nov 2010 10:19|
|Last Modified:||19 Nov 2010 10:19|
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