Schönenberger, Helmut and Lippert, P. (1972) Cytostatics. 18. Carcinostatic and antimicrobial activity of acylated N-hemiacetals, aminals, and aminomethyl esters of dithiocarbamic acid. Archiv der Pharmazie 305 (6), pp. 427-441.
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Twenty-four title compds., RCONR1CH2R2 (I, R = Me, Ph, 3- or 4-pyridyl; R1 = H or RR1 = CH2CH2CO; R2 = OH, NMe2, S2CNMe2, NEt2, S2CNEt2, morpholino, morpholinothiocarbonylthio, 4-methyl-1-piperazinyl, and 4-methyl-1-piperazinylthiocarbonylthio), prepd. by known methods from RCONHR1 with HCHO and (or) amine and (or) CS2, showed in vivo carcinostatic and in vitro fungistatic effects, whereas they were ineffective against gram-pos. and gram-neg. bacteria. Yoshida sarcoma of rats was inhibited by 25-66%. The most effective compd. was N-(hydroxymethyl)acetamide [625-51-4]. The inhibitory effects of I were transitory and ceased after ceasing I administration. The effects of I against fungi increased in the order N-hemiacetal < aminal < ester. Compared with the isosteric beta -amino ketones and dithiourethanes, the fungistatic activity was low.
|Additional information (public):||CAN 77:109268 1-3 Pharmacodynamics 625-51-4; 3659-51-6; 5146-68-9; 13575-57-0; 38221-31-7; 38221-33-9; 38221-36-2; 38221-37-3 Role: BIOL (Biological study) (fungicide and neoplasm inhibitor); 3569-99-1P; 13314-97-1P; 13538-44-8P; 20973-55-1P; 38221-39-5P; 38221-40-8P; 38221-41-9P; 38221-43-1P; 38221-45-3P; 38221-46-4P; 38221-47-5P; 38221-49-7P; 38221-50-0P; 38221-51-1P; 38221-52-2P; 38221-53-3P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Fungicides and Fungistats Neoplasm inhibitors (dithiocarbamic acid derivs.) aminal carcinostatic fungistatic thiocarbamate deriv carcinostatic fungistatic acetal carcinostatic fungistatic antitumor carbamate deriv|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||19 Nov 2010 09:06|
|Last Modified:||19 Nov 2010 09:06|