Schönenberger, Helmut and Lippert, P. (1972) Cytostatics. 16. Antimicrobial and tumor-inhibiting properties of dithiourethane and studies on the mechanism of action. Pharmazie 27 (3), pp. 139-145.
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Of 8 dithiourethanes and 4 dithiocarbamates tested for antimicrobial activity against 22 microorganisms, 6 had expressed fungistatic activity, 3-oxo-3-phenylpropyl N,N-dimethyldithiocarbamate (I) [30670-17-8] and Na N,N-dimethyldithiocarbamate [128-04-1] having the greatest effect. Only I and 3-oxobutyl N,N-dimethyldithiocarbamate [30538-01-3] had antibacterial activity, and none inhibited Yoshida sarcoma growth in rats or sarcoma 180 growth in mice. The corresponding dithiocarbamic acids, alpha ,beta -unsatd. ketones, and beta -ketones of the inactive dithiourethanes had increased fungistatic activity, whereas those derivs. of the active compds. were generally less effective. Cysteine-HCl [52-89-1], thioglycolic acid [68-11-1], and particularly bovine serum decreased the fungistatic effectiveness of the active compds. The antimicrobial properties of dithiourethanes depend on a complex interaction of different mechanisms, e.g. release of dithiocarbamic acid and alpha ,beta -unsatd. ketone, and acyl ethylation by dithiourethane.
|Additional information (public):||CAN 77:29579 3-2 Biochemical Interactions 128-04-1; 148-18-5; 873-58-5; 5712-49-2; 30538-01-3; 30538-02-4; 30538-03-5; 30650-96-5; 30650-97-6; 30650-98-7; 30670-17-8; 32465-67-1 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (cytostatic activity of); 52-89-1; 68-11-1 Role: PRP (Properties) (fungistatic activity of dithiourethanes in relation to)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Bactericides, Disinfectants and Antiseptics Fungicides and Fungistats Neoplasm inhibitors (dithiourethanes) dithiourethane fungistatic antibacterial dithiourethane dithiocarbamate fungistatic|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||19 Nov 2010 09:04|
|Last Modified:||19 Nov 2010 09:04|