Schönenberger, Helmut and Petter, A. and Beck, D. and Endres, W. and Servatius, H. J. (1976) Studies on the mechanisms of action of local anesthetics. Part 9. N-Aminoacyl-beta -phenylalkylamine studies for the development of antidepressants from psychostimulants. Pharmazie 31 (12), pp. 882-886.
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Of 10 N-L-phenylalanyl-beta -phenylalkylamines[PhCH2CH(NH2)CONR3CHR2CHR1Ph] (I, R1 = H or OH; R2 and R3 = H or Me) prepd. and tested as antidepressants, I(R1 = H; R2 and R3 = Me) [61925-95-9] and I(R1 = OH; R2 = Me; R3 = H) (II) [61950-64-9] were the most active compds. in the inhibition of cond. in strips of frog heart ventrical, I(R1 and R3 = H; R2 = Me) (III) [61925-94-8] and II were the most ...
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|Additional Information (public):||CAN 86:182950 1-3 Pharmacodynamics 5123-55-7 Role: RCT (Reactant), RACT (Reactant or reagent) (chlorination of); 35402-94-9P; 61925-91-5P; 61925-92-6P; 61925-93-7P; 61925-94-8P; 61925-95-9P; 61950-61-6P; 61950-62-7P; 61950-63-8P; 61950-64-9P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. and antidepressant activity of); 32150-91-7P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction of, with amines)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger|
|Keywords:||Antidepressants (phenylalanylphenylalkylamines) Molecular structure-biological activity relationship (antidepressant, of aminoacylphenylalkylamines) phenylalanylphenylalkylamine antidepressant|
|Dewey Decimal Classification:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||19 Nov 2010 09:02|
|Last Modified:||19 Nov 2010 09:02|