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Studies on the mechanisms of action of local anesthetics. Part 9. N-Aminoacyl-beta -phenylalkylamine studies for the development of antidepressants from psychostimulants

Schönenberger, Helmut and Petter, A. and Beck, D. and Endres, W. and Servatius, H. J. (1976) Studies on the mechanisms of action of local anesthetics. Part 9. N-Aminoacyl-beta -phenylalkylamine studies for the development of antidepressants from psychostimulants. Pharmazie 31 (12), pp. 882-886.

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Abstract

Of 10 N-L-phenylalanyl-beta -phenylalkylamines[PhCH2CH(NH2)CONR3CHR2CHR1Ph] (I, R1 = H or OH; R2 and R3 = H or Me) prepd. and tested as antidepressants, I(R1 = H; R2 and R3 = Me) [61925-95-9] and I(R1 = OH; R2 = Me; R3 = H) (II) [61950-64-9] were the most active compds. in the inhibition of cond. in strips of frog heart ventrical, I(R1 and R3 = H; R2 = Me) (III) [61925-94-8] and II were the most ...

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Item Type:Article
Date:1976
Additional information (public):CAN 86:182950 1-3 Pharmacodynamics 5123-55-7 Role: RCT (Reactant), RACT (Reactant or reagent) (chlorination of); 35402-94-9P; 61925-91-5P; 61925-92-6P; 61925-93-7P; 61925-94-8P; 61925-95-9P; 61950-61-6P; 61950-62-7P; 61950-63-8P; 61950-64-9P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. and antidepressant activity of); 32150-91-7P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction of, with amines)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Identification Number:
ValueType
1977:182950Other
Keywords:Antidepressants (phenylalanylphenylalkylamines) Molecular structure-biological activity relationship (antidepressant, of aminoacylphenylalkylamines) phenylalanylphenylalkylamine antidepressant
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Petra Gürster
Deposited On:19 Nov 2010 09:02
Last Modified:19 Nov 2010 09:02
Item ID:18171
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