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Azomethines and oxazolidines of norfenefrine. Development of compounds with long-lasting blood pressure raising activity

Schönenberger, Helmut and Petter, A. and Kühling, V. (1975) Azomethines and oxazolidines of norfenefrine. Development of compounds with long-lasting blood pressure raising activity. Archiv der Pharmazie 308 (9), pp. 717-719.

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Abstract

The condensation of 3-HOC6H4CH(OH)CH2NH2 with RR1CO gave 3-HOC6H4CH(OH)CH2N:CHR [R = Ph, 3-anisyl, 3,4-(MeO)2C6H3] and oxazolidines I (R1 = H, R = same as above; R = R1 = Me). The azomethines administered to cats in doses of 0.5 * 10-6 and 1 * 10-6 moles/kg i.v. showed antihypotensive activity similar to ...

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Item Type:Article
Date:1975
Additional information (public):CAN 84:17202 28-6 Heterocyclic Compounds (More Than One Hetero Atom) 536-21-0 Role: RCT (Reactant), RACT (Reactant or reagent) (condensation with aldehydes and ketones, azomethines and oxazolidines from); 67-64-1; 100-52-7; 120-14-9; 591-31-1 Role: RCT (Reactant), RACT (Reactant or reagent) (condensation with norfenefrine); 25283-28-7P; 57614-93-4P; 57614-94-5P; 57614-95-6P; 57614-96-7P; 57614-97-8P; 57614-98-9P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Identification Number:
ValueType
1976:17202Other
Keywords:Antihypertensives (norfenefrine azomethines) Ring closure and formation (oxazolidines from norfenefrine and aldehydes and ketones) antihypotensive norfenefrine azomethine hypertensive norfenefrine azomethine oxazolidine hydroxyphenyl cyclization norfenefrine aldehyde ketone condensation norfenefrine aldehyde ketone
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Petra Gürster
Deposited On:19 Nov 2010 09:00
Last Modified:19 Nov 2010 09:00
Item ID:18173
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