Deutsch
Schönenberger, Helmut and Petter, A. and Kühling, V. (1975) Azomethines and oxazolidines of norfenefrine. Development of compounds with long-lasting blood pressure raising activity. Archiv der Pharmazie 308 (9), pp. 717-719.
Full text not available from this repository.
Abstract
The condensation of 3-HOC6H4CH(OH)CH2NH2 with RR1CO gave 3-HOC6H4CH(OH)CH2N:CHR [R = Ph, 3-anisyl, 3,4-(MeO)2C6H3] and oxazolidines I (R1 = H, R = same as above; R = R1 = Me). The azomethines administered to cats in doses of 0.5 * 10-6 and 1 * 10-6 moles/kg i.v. showed antihypotensive activity similar to norfenefrine.
| Item Type: | Article | ||||
|---|---|---|---|---|---|
| Additional information (public): | CAN 84:17202 28-6 Heterocyclic Compounds (More Than One Hetero Atom) 536-21-0 Role: RCT (Reactant), RACT (Reactant or reagent) (condensation with aldehydes and ketones, azomethines and oxazolidines from); 67-64-1; 100-52-7; 120-14-9; 591-31-1 Role: RCT (Reactant), RACT (Reactant or reagent) (condensation with norfenefrine); 25283-28-7P; 57614-93-4P; 57614-94-5P; 57614-95-6P; 57614-96-7P; 57614-97-8P; 57614-98-9P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of) | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger | ||||
| Identification Number: |
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| Keywords: | Antihypertensives (norfenefrine azomethines) Ring closure and formation (oxazolidines from norfenefrine and aldehydes and ketones) antihypotensive norfenefrine azomethine hypertensive norfenefrine azomethine oxazolidine hydroxyphenyl cyclization norfenefrine aldehyde ketone condensation norfenefrine aldehyde ketone | ||||
| Subjects: | 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Unknown | ||||
| Owner: | Petra Gürster | ||||
| Deposited On: | 19 Nov 2010 10:00 | ||||
| Last Modified: | 19 Nov 2010 10:00 | ||||
| Item ID: | 18173 |
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