Schönenberger, Helmut and Petter, Alfred and Zwez, W. (1968) Mode of action of local anesthetics. Mitteilungen der Deutschen Pharmazeutischen Gesellschaft und der Pharmazeutischen Gesellschaft in der DDR 38 (11), pp. 209-221.
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A review is given in which the following topics were discussed: the ion canal as site of action of local anesthetics, effect of local anesthetics on the stimulation of nerves, binding of local anesthetics (ephedrine derivs.), and activity studies with enantiomeric local anesthetics (i.e. dimethylalanine derivs.) at various pH. The action of the local anesthetics involves the inhibition of permeability processes, which are increased by mobile membrane structures. The quant. graduation of single activities can be explained by the different chem. structure of the cellular components.
|Additional information (public):||CAN 70:45833 15 Pharmacodynamics|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Anesthetics (pharmacology of local) anesthetics mechanism review review mechanism anesthetics|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||19 Nov 2010 08:57|
|Last Modified:||19 Nov 2010 08:57|