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Action mechanism of local anesthetics. 3. Correlation between lipid solubility and biological action of homologous local anesthetics

Schönenberger, Helmut and Petter, A. and Zwez, W. (1972) Action mechanism of local anesthetics. 3. Correlation between lipid solubility and biological action of homologous local anesthetics. Pharmazie 27 (8), pp. 522-523.

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Abstract

A review with 9 refs. An increase alkoxy chain length of cinchocaine (I) [61-12-1] homologs by -CH2 groups up to the butoxy deriv., was assocd. with an increased neg. free energy of reaction (-Delta F0), lipid soly., protein binding, and an increased surface anesthetic activity. With the amyloxy and hexyloxy homologs of I, the lipid soly. and anesthetic activity decreased.

Item Type:

Article

Additional information (public):

CAN 77:159957 1-0 Pharmacodynamics 61-12-1D (4-Quinolinecarboxamide, 2-butoxy-N-[2-(diethylamino)ethyl]-, monohydrochloride) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (local anesthetic activity of)

Institutions:

Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger

Identification Number:

Value	Type
1972:559957	Other

Keywords:

Molecular structure-biological activity relationship (local anesthetic, of cinchocaine homologs) Anesthetics (local, cinchocaine homologs as) review anesthetic lipid soly cinchocaine anesthetic soly review

Subjects:

500 Science > 540 Chemistry & allied sciences

Status:

Published

Refereed:

Yes, this version has been refereed

Created at the University of Regensburg:

Unknown

Owner:

Petra Gürster

Deposited On:

19 Nov 2010 09:52