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Action mechanism of local anesthetics. 3. Correlation between lipid solubility and biological action of homologous local anesthetics

Schönenberger, Helmut ; Petter, A. ; Zwez, W.



Zusammenfassung

A review with 9 refs. An increase alkoxy chain length of cinchocaine (I) [61-12-1] homologs by -CH2 groups up to the butoxy deriv., was assocd. with an increased neg. free energy of reaction (-Delta F0), lipid soly., protein binding, and an increased surface anesthetic activity. With the amyloxy and hexyloxy homologs of I, the lipid soly. and anesthetic activity decreased.


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