Schönenberger, Helmut and Petter, A. and Zwez, W. (1972) Action mechanism of local anesthetics. 3. Correlation between lipid solubility and biological action of homologous local anesthetics. Pharmazie 27 (8), pp. 522-523.
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A review with 9 refs. An increase alkoxy chain length of cinchocaine (I) [61-12-1] homologs by -CH2 groups up to the butoxy deriv., was assocd. with an increased neg. free energy of reaction (-Delta F0), lipid soly., protein binding, and an increased surface anesthetic activity. With the amyloxy and hexyloxy homologs of I, the lipid soly. and anesthetic activity decreased.
|Additional information (public):||CAN 77:159957 1-0 Pharmacodynamics 61-12-1D (4-Quinolinecarboxamide, 2-butoxy-N-[2-(diethylamino)ethyl]-, monohydrochloride) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (local anesthetic activity of)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Molecular structure-biological activity relationship (local anesthetic, of cinchocaine homologs) Anesthetics (local, cinchocaine homologs as) review anesthetic lipid soly cinchocaine anesthetic soly review|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||19 Nov 2010 08:52|
|Last Modified:||19 Nov 2010 08:52|