Schönenberger, R. and Sunkel, C. and Schönenberger, Helmut (1972) Cytostatics. 19. Configurative assignment of diastereomer N,N'-dialkyl-alpha ,alpha '-diphenylethylenediamines by nuclear resonance spectroscopy. Arzneimittel-Forschung = Drug research 22 (11), pp. 1952-1955.
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The assignment of the configuration of o-R1C6H4CH(NHR)CH(NHR)C6H4R1-o (I; R = H, Bu, or Me2CHCH2; R1 = H or Cl) by PMR used the different chem. shifts of the ethylene protons (alpha -H) and arom. protons. The meso form exhibited a paramagnetic shift for the arom. protons and a diamagnetic shift for alpha -H compared to the racemic form. Corresponding differences were obsd. in the spectra of the cis and trans forms of II (X = S or H2), prepd. by reaction of I with CS2 or HCHO, resp. In contrast to I the signals of the arom. H of the cis forms of II were situated at higher field and the alpha -H signals at lower field compared to the trans forms owing to the different interactions between arom. rings. and the alpha -protons.
|Additional information (public):||CAN 78:71235 22-9 Physical Organic Chemistry 40102-61-2; 40102-62-3; 40102-63-4; 40102-64-5; 40102-65-6; 40102-66-7; 40102-67-8; 40102-68-9; 40102-69-0; 40102-70-3; 40102-71-4; 40102-72-5; 40102-73-6; 40102-74-7; 40102-75-8; 40102-76-9; 40102-77-0; 40102-78-1; 40102-79-2; 40102-80-5; 40102-81-6; 40102-82-7; 40102-83-8; 40102-84-9 Role: PRP (Properties) (configuration and PMR of)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Configuration (of dialkyldiphenylethylenediamines and -imidazolidine derivs.) NMR ethylenediamine imidazolidine diphenyl NMR configuration diphenylethylenediamine|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||19 Nov 2010 07:05|
|Last Modified:||19 Nov 2010 07:05|